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Inhaled corticosteroids downregulate SARS-CoV-2-related genes in COPD: results from a randomised controlled trial

In a RCT of 63 patients with COPD, 12 weeks of ICS/LABA therapy downregulated bronchial epithelial expression of the SARS-CoV-2-related genes ACE2 and ADAM17 compared to LABA alone. This may have implications for COVID-19 susceptibility/severity in COPD. https://bit.ly/3vZnBVO

Detalles Bibliográficos
Autores principales:	Milne, Stephen, Li, Xuan, Yang, Chen Xi, Leitao Filho, Fernando Sergio, Hernández Cordero, Ana I., Yang, Cheng Wei Tony, Shaipanich, Tawimas, van Eeden, Stephan F., Leung, Janice M., Lam, Stephen, Sin, Don D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	European Respiratory Society 2021
Materias:	Agora
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015643/ https://www.ncbi.nlm.nih.gov/pubmed/33795322 http://dx.doi.org/10.1183/13993003.00130-2021

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