Cargando…

Interorganelle communication, aging, and neurodegeneration

Our cells are comprised of billions of proteins, lipids, and other small molecules packed into their respective subcellular organelles, with the daunting task of maintaining cellular homeostasis over a lifetime. However, it is becoming increasingly evident that organelles do not act as autonomous di...

Descripción completa

Detalles Bibliográficos
Autores principales: Petkovic, Maja, O'Brien, Caitlin E., Jan, Yuh Nung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015714/
https://www.ncbi.nlm.nih.gov/pubmed/33861720
http://dx.doi.org/10.1101/gad.346759.120
_version_ 1783673732333568000
author Petkovic, Maja
O'Brien, Caitlin E.
Jan, Yuh Nung
author_facet Petkovic, Maja
O'Brien, Caitlin E.
Jan, Yuh Nung
author_sort Petkovic, Maja
collection PubMed
description Our cells are comprised of billions of proteins, lipids, and other small molecules packed into their respective subcellular organelles, with the daunting task of maintaining cellular homeostasis over a lifetime. However, it is becoming increasingly evident that organelles do not act as autonomous discrete units but rather as interconnected hubs that engage in extensive communication through membrane contacts. In the last few years, our understanding of how these contacts coordinate organelle function has redefined our view of the cell. This review aims to present novel findings on the cellular interorganelle communication network and how its dysfunction may contribute to aging and neurodegeneration. The consequences of disturbed interorganellar communication are intimately linked with age-related pathologies. Given that both aging and neurodegenerative diseases are characterized by the concomitant failure of multiple cellular pathways, coordination of organelle communication and function could represent an emerging regulatory mechanism critical for long-term cellular homeostasis. We anticipate that defining the relationships between interorganelle communication, aging, and neurodegeneration will open new avenues for therapeutics.
format Online
Article
Text
id pubmed-8015714
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Cold Spring Harbor Laboratory Press
record_format MEDLINE/PubMed
spelling pubmed-80157142021-04-21 Interorganelle communication, aging, and neurodegeneration Petkovic, Maja O'Brien, Caitlin E. Jan, Yuh Nung Genes Dev Review Our cells are comprised of billions of proteins, lipids, and other small molecules packed into their respective subcellular organelles, with the daunting task of maintaining cellular homeostasis over a lifetime. However, it is becoming increasingly evident that organelles do not act as autonomous discrete units but rather as interconnected hubs that engage in extensive communication through membrane contacts. In the last few years, our understanding of how these contacts coordinate organelle function has redefined our view of the cell. This review aims to present novel findings on the cellular interorganelle communication network and how its dysfunction may contribute to aging and neurodegeneration. The consequences of disturbed interorganellar communication are intimately linked with age-related pathologies. Given that both aging and neurodegenerative diseases are characterized by the concomitant failure of multiple cellular pathways, coordination of organelle communication and function could represent an emerging regulatory mechanism critical for long-term cellular homeostasis. We anticipate that defining the relationships between interorganelle communication, aging, and neurodegeneration will open new avenues for therapeutics. Cold Spring Harbor Laboratory Press 2021-04-01 /pmc/articles/PMC8015714/ /pubmed/33861720 http://dx.doi.org/10.1101/gad.346759.120 Text en © 2021 Petkovic et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article, published in Genes & Development, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Review
Petkovic, Maja
O'Brien, Caitlin E.
Jan, Yuh Nung
Interorganelle communication, aging, and neurodegeneration
title Interorganelle communication, aging, and neurodegeneration
title_full Interorganelle communication, aging, and neurodegeneration
title_fullStr Interorganelle communication, aging, and neurodegeneration
title_full_unstemmed Interorganelle communication, aging, and neurodegeneration
title_short Interorganelle communication, aging, and neurodegeneration
title_sort interorganelle communication, aging, and neurodegeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015714/
https://www.ncbi.nlm.nih.gov/pubmed/33861720
http://dx.doi.org/10.1101/gad.346759.120
work_keys_str_mv AT petkovicmaja interorganellecommunicationagingandneurodegeneration
AT obriencaitline interorganellecommunicationagingandneurodegeneration
AT janyuhnung interorganellecommunicationagingandneurodegeneration