Cargando…
Human nucleoli comprise multiple constrained territories, tethered to individual chromosomes
It is unknown how ribosomal gene (rDNA) arrays from multiple chromosomal nucleolar organizers (NORs) partition within human nucleoli. Exploration of this paradigm for chromosomal organization is complicated by the shared DNA sequence composition of five NOR-bearing acrocentric chromosome p-arms. Her...
Autores principales: | Mangan, Hazel, McStay, Brian |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015717/ https://www.ncbi.nlm.nih.gov/pubmed/33664058 http://dx.doi.org/10.1101/gad.348234.121 |
Ejemplares similares
-
NORs on human acrocentric chromosome p-arms are active by default and can associate with nucleoli independently of rDNA
por: van Sluis, Marjolein, et al.
Publicado: (2020) -
Human NORs, comprising rDNA arrays and functionally conserved distal elements, are located within dynamic chromosomal regions
por: van Sluis, Marjolein, et al.
Publicado: (2019) -
Construction of synthetic nucleoli in human cells reveals how a major functional nuclear domain is formed and propagated through cell division
por: Grob, Alice, et al.
Publicado: (2014) -
Resolution of human ribosomal DNA occurs in anaphase, dependent on tankyrase 1, condensin II, and topoisomerase IIα
por: Daniloski, Zharko, et al.
Publicado: (2019) -
Nucleolar organizer regions: genomic ‘dark matter’ requiring illumination
por: McStay, Brian
Publicado: (2016)