RAD21 is a driver of chromosome 8 gain in Ewing sarcoma to mitigate replication stress

Aneuploidy, defined as whole-chromosome gain or loss, causes cellular stress but, paradoxically, is a frequent occurrence in cancers. Here, we investigate why ∼50% of Ewing sarcomas, driven by the EWS-FLI1 fusion oncogene, harbor chromosome 8 gains. Expression of the EWS-FLI1 fusion in primary cells...

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Detalles Bibliográficos
Autores principales: Su, Xiaofeng A., Ma, Duanduan, Parsons, James V., Replogle, John M., Amatruda, James F., Whittaker, Charles A., Stegmaier, Kimberly, Amon, Angelika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015718/
https://www.ncbi.nlm.nih.gov/pubmed/33766983
http://dx.doi.org/10.1101/gad.345454.120

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