WWTR1(TAZ)-CAMTA1 gene fusion is sufficient to dysregulate YAP/TAZ signaling and drive epithelioid hemangioendothelioma tumorigenesis

Epithelioid hemangioendothelioma (EHE) is a genetically homogenous vascular sarcoma that is a paradigm for TAZ dysregulation in cancer. EHE harbors a WWTR1(TAZ)-CAMTA1 gene fusion in >90% of cases, 45% of which have no other genetic alterations. In this study, we used a first of its kind approach...

Descripción completa

Detalles Bibliográficos
Autores principales: Seavey, Caleb N., Pobbati, Ajaybabu V., Hallett, Andrea, Ma, Shuang, Reynolds, Jordan P., Kanai, Ryan, Lamar, John M., Rubin, Brian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015722/
https://www.ncbi.nlm.nih.gov/pubmed/33766982
http://dx.doi.org/10.1101/gad.348220.120

Ejemplares similares

Ejemplares similares