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Revealing Donor Substrate-Dependent Mechanistic Control on DXPS, an Enzyme in Bacterial Central Metabolism

[Image: see text] The thiamin diphosphate-dependent enzyme 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) catalyzes the formation of DXP from pyruvate (donor) and d-glyceraldehyde 3-phosphate (d-GAP, acceptor). DXPS is essential in bacteria but absent in human metabolism, highlighting it as a potent...

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Detalles Bibliográficos
Autores principales:	Johnston, Melanie L., Freel Meyers, Caren L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015787/ https://www.ncbi.nlm.nih.gov/pubmed/33660509 http://dx.doi.org/10.1021/acs.biochem.1c00019

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