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Evaluation of the ATN model in a longitudinal memory clinic sample with different underlying disorders

INTRODUCTION: To evaluate the usefulness of the 2018 NIA‐AA (National Institute on Aging and Alzheimer's Association) research framework in a longitudinal memory clinic study with different clinical outcomes and underlying disorders. METHODS: We included 420 patients with mild cognitive impairm...

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Autores principales: Eckerström, C., Svensson, J., Kettunen, P., Jonsson, M., Eckerström, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015813/
https://www.ncbi.nlm.nih.gov/pubmed/33816750
http://dx.doi.org/10.1002/dad2.12031
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author Eckerström, C.
Svensson, J.
Kettunen, P.
Jonsson, M.
Eckerström, M.
author_facet Eckerström, C.
Svensson, J.
Kettunen, P.
Jonsson, M.
Eckerström, M.
author_sort Eckerström, C.
collection PubMed
description INTRODUCTION: To evaluate the usefulness of the 2018 NIA‐AA (National Institute on Aging and Alzheimer's Association) research framework in a longitudinal memory clinic study with different clinical outcomes and underlying disorders. METHODS: We included 420 patients with mild cognitive impairment or subjective cognitive impairment. During the follow up, 27% of the patients converted to dementia, with the majority converting to Alzheimer's disease (AD) or mixed dementia. Based on the baseline values of the cerebrospinal fluid biomarkers, the patients were classified into one of the eight possible ATN groups (amyloid beta [Aβ] aggregation [A], tau aggregation reflecting neurofibrillary tangles [T], and neurodegeneration [N]). RESULTS: The majority of the patients converting to AD and mixed dementia were in ATN groups positive for A (71%). The A+T+N+ group was highly overrepresented among converters to AD and mixed dementia. Patients converting to dementias other than AD or mixed dementia were evenly distributed across the ATN groups DISCUSSION: Our findings provide support for the usefulness of the ATN system to detect incipient AD or mixed dementia.
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spelling pubmed-80158132021-04-02 Evaluation of the ATN model in a longitudinal memory clinic sample with different underlying disorders Eckerström, C. Svensson, J. Kettunen, P. Jonsson, M. Eckerström, M. Alzheimers Dement (Amst) Diagnostic Assessment & Prognosis INTRODUCTION: To evaluate the usefulness of the 2018 NIA‐AA (National Institute on Aging and Alzheimer's Association) research framework in a longitudinal memory clinic study with different clinical outcomes and underlying disorders. METHODS: We included 420 patients with mild cognitive impairment or subjective cognitive impairment. During the follow up, 27% of the patients converted to dementia, with the majority converting to Alzheimer's disease (AD) or mixed dementia. Based on the baseline values of the cerebrospinal fluid biomarkers, the patients were classified into one of the eight possible ATN groups (amyloid beta [Aβ] aggregation [A], tau aggregation reflecting neurofibrillary tangles [T], and neurodegeneration [N]). RESULTS: The majority of the patients converting to AD and mixed dementia were in ATN groups positive for A (71%). The A+T+N+ group was highly overrepresented among converters to AD and mixed dementia. Patients converting to dementias other than AD or mixed dementia were evenly distributed across the ATN groups DISCUSSION: Our findings provide support for the usefulness of the ATN system to detect incipient AD or mixed dementia. John Wiley and Sons Inc. 2021-04-01 /pmc/articles/PMC8015813/ /pubmed/33816750 http://dx.doi.org/10.1002/dad2.12031 Text en © 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, Inc. on behalf of the Alzheimer's Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Diagnostic Assessment & Prognosis
Eckerström, C.
Svensson, J.
Kettunen, P.
Jonsson, M.
Eckerström, M.
Evaluation of the ATN model in a longitudinal memory clinic sample with different underlying disorders
title Evaluation of the ATN model in a longitudinal memory clinic sample with different underlying disorders
title_full Evaluation of the ATN model in a longitudinal memory clinic sample with different underlying disorders
title_fullStr Evaluation of the ATN model in a longitudinal memory clinic sample with different underlying disorders
title_full_unstemmed Evaluation of the ATN model in a longitudinal memory clinic sample with different underlying disorders
title_short Evaluation of the ATN model in a longitudinal memory clinic sample with different underlying disorders
title_sort evaluation of the atn model in a longitudinal memory clinic sample with different underlying disorders
topic Diagnostic Assessment & Prognosis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015813/
https://www.ncbi.nlm.nih.gov/pubmed/33816750
http://dx.doi.org/10.1002/dad2.12031
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