ZNF91 deletion in human embryonic stem cells leads to ectopic activation of SVA retrotransposons and up-regulation of KRAB zinc finger gene clusters

Transposable element (TE) invasions have shaped vertebrate genomes over the course of evolution. They have contributed an extra layer of species-specific gene regulation by providing novel transcription factor binding sites. In humans, SINE-VNTR-Alu (SVA) elements are one of three still active TE fa...

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Detalles Bibliográficos
Autores principales: Haring, Nina L., van Bree, Elisabeth J., Jordaan, Whitney S., Roels, Judith R.E., Sotomayor, Gonzalo Congrains, Hey, Tiziana M., White, Fred T.G., Galland, Marc D., Smidt, Marten P., Jacobs, Frank M.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015857/
https://www.ncbi.nlm.nih.gov/pubmed/33722937
http://dx.doi.org/10.1101/gr.265348.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015857/
https://www.ncbi.nlm.nih.gov/pubmed/33722937
http://dx.doi.org/10.1101/gr.265348.120

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