Seeded assembly in vitro does not replicate the structures of α‐synuclein filaments from multiple system atrophy

The propagation of conformational strains by templated seeding is central to the prion concept. Seeded assembly of α‐synuclein into filaments is believed to underlie the prion‐like spreading of protein inclusions in a number of human neurodegenerative diseases, including Parkinson's disease, de...

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Detalles Bibliográficos
Autores principales: Lövestam, Sofia, Schweighauser, Manuel, Matsubara, Tomoyasu, Murayama, Shigeo, Tomita, Taisuke, Ando, Takashi, Hasegawa, Kazuko, Yoshida, Mari, Tarutani, Airi, Hasegawa, Masato, Goedert, Michel, Scheres, Sjors H. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016116/
https://www.ncbi.nlm.nih.gov/pubmed/33548114
http://dx.doi.org/10.1002/2211-5463.13110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016116/
https://www.ncbi.nlm.nih.gov/pubmed/33548114
http://dx.doi.org/10.1002/2211-5463.13110

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