AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides

[Image: see text] We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.

Detalles Bibliográficos
Autores principales: Acevedo-Jake, Amanda, Ball, Andrew T., Galli, Marzia, Kukwikila, Mikiembo, Denis, Mathieu, Singleton, Daniel G., Tavassoli, Ali, Goldup, Stephen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016193/
https://www.ncbi.nlm.nih.gov/pubmed/32155338
http://dx.doi.org/10.1021/jacs.0c01670
Descripción
Sumario:[Image: see text] We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.

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