AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides

[Image: see text] We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.

Detalles Bibliográficos
Autores principales: Acevedo-Jake, Amanda, Ball, Andrew T., Galli, Marzia, Kukwikila, Mikiembo, Denis, Mathieu, Singleton, Daniel G., Tavassoli, Ali, Goldup, Stephen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016193/
https://www.ncbi.nlm.nih.gov/pubmed/32155338
http://dx.doi.org/10.1021/jacs.0c01670
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author Acevedo-Jake, Amanda
Ball, Andrew T.
Galli, Marzia
Kukwikila, Mikiembo
Denis, Mathieu
Singleton, Daniel G.
Tavassoli, Ali
Goldup, Stephen M.
author_facet Acevedo-Jake, Amanda
Ball, Andrew T.
Galli, Marzia
Kukwikila, Mikiembo
Denis, Mathieu
Singleton, Daniel G.
Tavassoli, Ali
Goldup, Stephen M.
author_sort Acevedo-Jake, Amanda
collection PubMed
description [Image: see text] We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.
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spelling pubmed-80161932021-04-05 AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides Acevedo-Jake, Amanda Ball, Andrew T. Galli, Marzia Kukwikila, Mikiembo Denis, Mathieu Singleton, Daniel G. Tavassoli, Ali Goldup, Stephen M. J Am Chem Soc [Image: see text] We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties. American Chemical Society 2020-03-10 2020-04-01 /pmc/articles/PMC8016193/ /pubmed/32155338 http://dx.doi.org/10.1021/jacs.0c01670 Text en Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Acevedo-Jake, Amanda
Ball, Andrew T.
Galli, Marzia
Kukwikila, Mikiembo
Denis, Mathieu
Singleton, Daniel G.
Tavassoli, Ali
Goldup, Stephen M.
AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides
title AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides
title_full AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides
title_fullStr AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides
title_full_unstemmed AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides
title_short AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides
title_sort at-cuaac synthesis of mechanically interlocked oligonucleotides
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016193/
https://www.ncbi.nlm.nih.gov/pubmed/32155338
http://dx.doi.org/10.1021/jacs.0c01670
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