Cargando…

Predicting the cumulative medical load of COVID-19 outbreaks after the peak in daily fatalities

The distinct ways the COVID-19 pandemic has been unfolding in different countries and regions suggest that local societal and governmental structures play an important role not only for the baseline infection rate, but also for short and long-term reactions to the outbreak. We propose to investigate...

Descripción completa

Detalles Bibliográficos
Autores principales: Gros, Claudius, Valenti, Roser, Schneider, Lukas, Gutsche, Benedikt, Marković, Dimitrije
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016333/
https://www.ncbi.nlm.nih.gov/pubmed/33793551
http://dx.doi.org/10.1371/journal.pone.0247272
_version_ 1783673838836383744
author Gros, Claudius
Valenti, Roser
Schneider, Lukas
Gutsche, Benedikt
Marković, Dimitrije
author_facet Gros, Claudius
Valenti, Roser
Schneider, Lukas
Gutsche, Benedikt
Marković, Dimitrije
author_sort Gros, Claudius
collection PubMed
description The distinct ways the COVID-19 pandemic has been unfolding in different countries and regions suggest that local societal and governmental structures play an important role not only for the baseline infection rate, but also for short and long-term reactions to the outbreak. We propose to investigate the question of how societies as a whole, and governments in particular, modulate the dynamics of a novel epidemic using a generalization of the SIR model, the reactive SIR (short-term and long-term reaction) model. We posit that containment measures are equivalent to a feedback between the status of the outbreak and the reproduction factor. Short-term reaction to an outbreak corresponds in this framework to the reaction of governments and individuals to daily cases and fatalities. The reaction to the cumulative number of cases or deaths, and not to daily numbers, is captured in contrast by long-term reaction. We present the exact phase space solution of the controlled SIR model and use it to quantify containment policies for a large number of countries in terms of short and long-term control parameters. We find increased contributions of long-term control for countries and regions in which the outbreak was suppressed substantially together with a strong correlation between the strength of societal and governmental policies and the time needed to contain COVID-19 outbreaks. Furthermore, for numerous countries and regions we identified a predictive relation between the number of fatalities within a fixed period before and after the peak of daily fatality counts, which allows to gauge the cumulative medical load of COVID-19 outbreaks that should be expected after the peak. These results suggest that the proposed model is applicable not only for understanding the outbreak dynamics, but also for predicting future cases and fatalities once the effectiveness of outbreak suppression policies is established with sufficient certainty. Finally, we provide a web app (https://itp.uni-frankfurt.de/covid-19/) with tools for visualising the phase space representation of real-world COVID-19 data and for exporting the preprocessed data for further analysis.
format Online
Article
Text
id pubmed-8016333
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-80163332021-04-08 Predicting the cumulative medical load of COVID-19 outbreaks after the peak in daily fatalities Gros, Claudius Valenti, Roser Schneider, Lukas Gutsche, Benedikt Marković, Dimitrije PLoS One Research Article The distinct ways the COVID-19 pandemic has been unfolding in different countries and regions suggest that local societal and governmental structures play an important role not only for the baseline infection rate, but also for short and long-term reactions to the outbreak. We propose to investigate the question of how societies as a whole, and governments in particular, modulate the dynamics of a novel epidemic using a generalization of the SIR model, the reactive SIR (short-term and long-term reaction) model. We posit that containment measures are equivalent to a feedback between the status of the outbreak and the reproduction factor. Short-term reaction to an outbreak corresponds in this framework to the reaction of governments and individuals to daily cases and fatalities. The reaction to the cumulative number of cases or deaths, and not to daily numbers, is captured in contrast by long-term reaction. We present the exact phase space solution of the controlled SIR model and use it to quantify containment policies for a large number of countries in terms of short and long-term control parameters. We find increased contributions of long-term control for countries and regions in which the outbreak was suppressed substantially together with a strong correlation between the strength of societal and governmental policies and the time needed to contain COVID-19 outbreaks. Furthermore, for numerous countries and regions we identified a predictive relation between the number of fatalities within a fixed period before and after the peak of daily fatality counts, which allows to gauge the cumulative medical load of COVID-19 outbreaks that should be expected after the peak. These results suggest that the proposed model is applicable not only for understanding the outbreak dynamics, but also for predicting future cases and fatalities once the effectiveness of outbreak suppression policies is established with sufficient certainty. Finally, we provide a web app (https://itp.uni-frankfurt.de/covid-19/) with tools for visualising the phase space representation of real-world COVID-19 data and for exporting the preprocessed data for further analysis. Public Library of Science 2021-04-01 /pmc/articles/PMC8016333/ /pubmed/33793551 http://dx.doi.org/10.1371/journal.pone.0247272 Text en © 2021 Gros et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Gros, Claudius
Valenti, Roser
Schneider, Lukas
Gutsche, Benedikt
Marković, Dimitrije
Predicting the cumulative medical load of COVID-19 outbreaks after the peak in daily fatalities
title Predicting the cumulative medical load of COVID-19 outbreaks after the peak in daily fatalities
title_full Predicting the cumulative medical load of COVID-19 outbreaks after the peak in daily fatalities
title_fullStr Predicting the cumulative medical load of COVID-19 outbreaks after the peak in daily fatalities
title_full_unstemmed Predicting the cumulative medical load of COVID-19 outbreaks after the peak in daily fatalities
title_short Predicting the cumulative medical load of COVID-19 outbreaks after the peak in daily fatalities
title_sort predicting the cumulative medical load of covid-19 outbreaks after the peak in daily fatalities
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016333/
https://www.ncbi.nlm.nih.gov/pubmed/33793551
http://dx.doi.org/10.1371/journal.pone.0247272
work_keys_str_mv AT grosclaudius predictingthecumulativemedicalloadofcovid19outbreaksafterthepeakindailyfatalities
AT valentiroser predictingthecumulativemedicalloadofcovid19outbreaksafterthepeakindailyfatalities
AT schneiderlukas predictingthecumulativemedicalloadofcovid19outbreaksafterthepeakindailyfatalities
AT gutschebenedikt predictingthecumulativemedicalloadofcovid19outbreaksafterthepeakindailyfatalities
AT markovicdimitrije predictingthecumulativemedicalloadofcovid19outbreaksafterthepeakindailyfatalities