Cargando…

Effect of gut microbiota modulation on feeding tolerance of enterally fed critically ill adult patients: a systematic review

PURPOSE: The objective of this systematic review was to evaluate the effect of pre-, pro-, and synbiotics on feeding tolerance of enterally fed critically ill adult patients. METHODS: MEDLINE, Science Direct, Web of Knowledge, and the Cochrane Central Register of Controlled Trials were searched up t...

Descripción completa

Detalles Bibliográficos
Autores principales: Seifi, Najmeh, Jafarzadeh Esfahani, Ali, Sedaghat, Alireza, Rezvani, Reza, Khadem-Rezaiyan, Majid, Nematy, Mohsen, Safarian, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016507/
https://www.ncbi.nlm.nih.gov/pubmed/33794994
http://dx.doi.org/10.1186/s13643-021-01633-5
_version_ 1783673873137401856
author Seifi, Najmeh
Jafarzadeh Esfahani, Ali
Sedaghat, Alireza
Rezvani, Reza
Khadem-Rezaiyan, Majid
Nematy, Mohsen
Safarian, Mohammad
author_facet Seifi, Najmeh
Jafarzadeh Esfahani, Ali
Sedaghat, Alireza
Rezvani, Reza
Khadem-Rezaiyan, Majid
Nematy, Mohsen
Safarian, Mohammad
author_sort Seifi, Najmeh
collection PubMed
description PURPOSE: The objective of this systematic review was to evaluate the effect of pre-, pro-, and synbiotics on feeding tolerance of enterally fed critically ill adult patients. METHODS: MEDLINE, Science Direct, Web of Knowledge, and the Cochrane Central Register of Controlled Trials were searched up to November 2019. English language randomized controlled trials reporting the effect of pre, pro or synbiotics on the feeding tolerance of enterally fed critically ill adult patients were included. RESULTS: Overall, 15 papers were selected for review. Among six studies reporting the energy intake, only two studies showed significantly higher energy intake in the prebiotic-receiving groups. Among four RCTs reporting frequency or time to achieve the target calorie, only one found a significant effect of probiotics to reduce the time to achieve a target dose of calorie. About the prevalence or duration of diarrhea, 7 out of 12 RCTs reported a beneficial effect. All but one study found no beneficial effects for gut microbiota manipulation on clinical endpoints including length of stay (LOS) in hospital and intensive care unit (ICU). CONCLUSION: It should be noticed that the heterogeneity in study designs, product format, and ICU patient populations makes it difficult to draw any general conclusion. Overall, it seems that pre, pro, or synbiotics have no significant beneficial effect on feeding tolerance and clinical endpoints in critically ill adults, but they may reduce the prevalence or duration of diarrhea. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13643-021-01633-5.
format Online
Article
Text
id pubmed-8016507
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-80165072021-04-02 Effect of gut microbiota modulation on feeding tolerance of enterally fed critically ill adult patients: a systematic review Seifi, Najmeh Jafarzadeh Esfahani, Ali Sedaghat, Alireza Rezvani, Reza Khadem-Rezaiyan, Majid Nematy, Mohsen Safarian, Mohammad Syst Rev Research PURPOSE: The objective of this systematic review was to evaluate the effect of pre-, pro-, and synbiotics on feeding tolerance of enterally fed critically ill adult patients. METHODS: MEDLINE, Science Direct, Web of Knowledge, and the Cochrane Central Register of Controlled Trials were searched up to November 2019. English language randomized controlled trials reporting the effect of pre, pro or synbiotics on the feeding tolerance of enterally fed critically ill adult patients were included. RESULTS: Overall, 15 papers were selected for review. Among six studies reporting the energy intake, only two studies showed significantly higher energy intake in the prebiotic-receiving groups. Among four RCTs reporting frequency or time to achieve the target calorie, only one found a significant effect of probiotics to reduce the time to achieve a target dose of calorie. About the prevalence or duration of diarrhea, 7 out of 12 RCTs reported a beneficial effect. All but one study found no beneficial effects for gut microbiota manipulation on clinical endpoints including length of stay (LOS) in hospital and intensive care unit (ICU). CONCLUSION: It should be noticed that the heterogeneity in study designs, product format, and ICU patient populations makes it difficult to draw any general conclusion. Overall, it seems that pre, pro, or synbiotics have no significant beneficial effect on feeding tolerance and clinical endpoints in critically ill adults, but they may reduce the prevalence or duration of diarrhea. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13643-021-01633-5. BioMed Central 2021-04-02 /pmc/articles/PMC8016507/ /pubmed/33794994 http://dx.doi.org/10.1186/s13643-021-01633-5 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Seifi, Najmeh
Jafarzadeh Esfahani, Ali
Sedaghat, Alireza
Rezvani, Reza
Khadem-Rezaiyan, Majid
Nematy, Mohsen
Safarian, Mohammad
Effect of gut microbiota modulation on feeding tolerance of enterally fed critically ill adult patients: a systematic review
title Effect of gut microbiota modulation on feeding tolerance of enterally fed critically ill adult patients: a systematic review
title_full Effect of gut microbiota modulation on feeding tolerance of enterally fed critically ill adult patients: a systematic review
title_fullStr Effect of gut microbiota modulation on feeding tolerance of enterally fed critically ill adult patients: a systematic review
title_full_unstemmed Effect of gut microbiota modulation on feeding tolerance of enterally fed critically ill adult patients: a systematic review
title_short Effect of gut microbiota modulation on feeding tolerance of enterally fed critically ill adult patients: a systematic review
title_sort effect of gut microbiota modulation on feeding tolerance of enterally fed critically ill adult patients: a systematic review
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016507/
https://www.ncbi.nlm.nih.gov/pubmed/33794994
http://dx.doi.org/10.1186/s13643-021-01633-5
work_keys_str_mv AT seifinajmeh effectofgutmicrobiotamodulationonfeedingtoleranceofenterallyfedcriticallyilladultpatientsasystematicreview
AT jafarzadehesfahaniali effectofgutmicrobiotamodulationonfeedingtoleranceofenterallyfedcriticallyilladultpatientsasystematicreview
AT sedaghatalireza effectofgutmicrobiotamodulationonfeedingtoleranceofenterallyfedcriticallyilladultpatientsasystematicreview
AT rezvanireza effectofgutmicrobiotamodulationonfeedingtoleranceofenterallyfedcriticallyilladultpatientsasystematicreview
AT khademrezaiyanmajid effectofgutmicrobiotamodulationonfeedingtoleranceofenterallyfedcriticallyilladultpatientsasystematicreview
AT nematymohsen effectofgutmicrobiotamodulationonfeedingtoleranceofenterallyfedcriticallyilladultpatientsasystematicreview
AT safarianmohammad effectofgutmicrobiotamodulationonfeedingtoleranceofenterallyfedcriticallyilladultpatientsasystematicreview