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Prognostic Nomograms for Nonelderly Adults with Gastric Signet Ring Cell Carcinoma

BACKGROUND: Nomograms were established to predict the survival for gastric signet ring cell carcinoma (GSRC) in young and middle-aged adults. Material and Methods. Eligible patients with GSRC from 2004 to 2015 were collected from the Surveillance, Epidemiology, and End Results (SEER) database and th...

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Autores principales: Wang, Hui, Peng, Yao, Huang, Qi, Wu, Jingjing, Zhang, Mingjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016563/
https://www.ncbi.nlm.nih.gov/pubmed/33834061
http://dx.doi.org/10.1155/2021/1274527
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author Wang, Hui
Peng, Yao
Huang, Qi
Wu, Jingjing
Zhang, Mingjun
author_facet Wang, Hui
Peng, Yao
Huang, Qi
Wu, Jingjing
Zhang, Mingjun
author_sort Wang, Hui
collection PubMed
description BACKGROUND: Nomograms were established to predict the survival for gastric signet ring cell carcinoma (GSRC) in young and middle-aged adults. Material and Methods. Eligible patients with GSRC from 2004 to 2015 were collected from the Surveillance, Epidemiology, and End Results (SEER) database and then divided into a training and a testing cohort in proportion. Independent prognostic factors were picked by univariate and multivariate Cox regression analysis to set up nomograms. The predictive effect and clinical value of nomograms were evaluated by the concordance index (C-index), calibration curves, and receiver operating characteristic curve (ROC). RESULTS: A total of 1686 GSRC patients were subsumed into this case for analysis, including a training (n = 1180) and a testing cohort (n = 506). Independent risk factors related to overall survival (OS) and cancer-specific survival (CSS) comprised of race, TNM stage, tumor size, number of positive lymph nodes (PLNE), and chemotherapy. For OS, the C-indexes of the training and testing cohorts were 0.737 and 0.752, while for CSS, C-indexes were, respectively, 0.749 and 0.751. These revealed that nomograms accurately predicted OS and CSS. Calibration curves and ROC demonstrated the apparent superiority of nomograms. CONCLUSION: We built a well-understood and comprehensive prognostic assessment model for GSRC, which provided an individualized survival prediction in the form of a quantitative score that can be considered for clinical practice.
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spelling pubmed-80165632021-04-07 Prognostic Nomograms for Nonelderly Adults with Gastric Signet Ring Cell Carcinoma Wang, Hui Peng, Yao Huang, Qi Wu, Jingjing Zhang, Mingjun Biomed Res Int Research Article BACKGROUND: Nomograms were established to predict the survival for gastric signet ring cell carcinoma (GSRC) in young and middle-aged adults. Material and Methods. Eligible patients with GSRC from 2004 to 2015 were collected from the Surveillance, Epidemiology, and End Results (SEER) database and then divided into a training and a testing cohort in proportion. Independent prognostic factors were picked by univariate and multivariate Cox regression analysis to set up nomograms. The predictive effect and clinical value of nomograms were evaluated by the concordance index (C-index), calibration curves, and receiver operating characteristic curve (ROC). RESULTS: A total of 1686 GSRC patients were subsumed into this case for analysis, including a training (n = 1180) and a testing cohort (n = 506). Independent risk factors related to overall survival (OS) and cancer-specific survival (CSS) comprised of race, TNM stage, tumor size, number of positive lymph nodes (PLNE), and chemotherapy. For OS, the C-indexes of the training and testing cohorts were 0.737 and 0.752, while for CSS, C-indexes were, respectively, 0.749 and 0.751. These revealed that nomograms accurately predicted OS and CSS. Calibration curves and ROC demonstrated the apparent superiority of nomograms. CONCLUSION: We built a well-understood and comprehensive prognostic assessment model for GSRC, which provided an individualized survival prediction in the form of a quantitative score that can be considered for clinical practice. Hindawi 2021-03-24 /pmc/articles/PMC8016563/ /pubmed/33834061 http://dx.doi.org/10.1155/2021/1274527 Text en Copyright © 2021 Hui Wang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Hui
Peng, Yao
Huang, Qi
Wu, Jingjing
Zhang, Mingjun
Prognostic Nomograms for Nonelderly Adults with Gastric Signet Ring Cell Carcinoma
title Prognostic Nomograms for Nonelderly Adults with Gastric Signet Ring Cell Carcinoma
title_full Prognostic Nomograms for Nonelderly Adults with Gastric Signet Ring Cell Carcinoma
title_fullStr Prognostic Nomograms for Nonelderly Adults with Gastric Signet Ring Cell Carcinoma
title_full_unstemmed Prognostic Nomograms for Nonelderly Adults with Gastric Signet Ring Cell Carcinoma
title_short Prognostic Nomograms for Nonelderly Adults with Gastric Signet Ring Cell Carcinoma
title_sort prognostic nomograms for nonelderly adults with gastric signet ring cell carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016563/
https://www.ncbi.nlm.nih.gov/pubmed/33834061
http://dx.doi.org/10.1155/2021/1274527
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