A Case of Follicular Tumor of Uncertain Malignant Potential (FT-UMP) with Glomeruloid Features Showing Capsular Mucinous Degeneration

The most recent revision of the World Health Organization (WHO) Classification of Tumours of Endocrine Organs introduced a new variant of follicular thyroid carcinoma (FTC). It is characterized by a “glomeruloid” architectural pattern of growth. We present a case of follicular tumor with glomeruloid...

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Autores principales: Cabibi, Daniela, Mondello, Andrea, Florena, Ada Maria, Rimi, Giulia, Giannone, Antonino Giulio, Cipolla, Calogero, Valerio, Maria Rosaria, Graceffa, Giuseppa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016592/
https://www.ncbi.nlm.nih.gov/pubmed/33833889
http://dx.doi.org/10.1155/2021/1686025
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author Cabibi, Daniela
Mondello, Andrea
Florena, Ada Maria
Rimi, Giulia
Giannone, Antonino Giulio
Cipolla, Calogero
Valerio, Maria Rosaria
Graceffa, Giuseppa
author_facet Cabibi, Daniela
Mondello, Andrea
Florena, Ada Maria
Rimi, Giulia
Giannone, Antonino Giulio
Cipolla, Calogero
Valerio, Maria Rosaria
Graceffa, Giuseppa
author_sort Cabibi, Daniela
collection PubMed
description The most recent revision of the World Health Organization (WHO) Classification of Tumours of Endocrine Organs introduced a new variant of follicular thyroid carcinoma (FTC). It is characterized by a “glomeruloid” architectural pattern of growth. We present a case of follicular tumor with glomeruloid features, with Alcian Blue positive mucinous stromal degeneration in foci of questionable capsular microinvasion. At our knowledge, this the second case of glomeruloid follicular tumor in the literature and the first case in which Alcian Blue staining was used to investigate capsular invasion. Moreover, RAS mutation further supports that this is a variant of follicular tumor with uncertain malignant potential.
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spelling pubmed-80165922021-04-07 A Case of Follicular Tumor of Uncertain Malignant Potential (FT-UMP) with Glomeruloid Features Showing Capsular Mucinous Degeneration Cabibi, Daniela Mondello, Andrea Florena, Ada Maria Rimi, Giulia Giannone, Antonino Giulio Cipolla, Calogero Valerio, Maria Rosaria Graceffa, Giuseppa Case Rep Pathol Case Report The most recent revision of the World Health Organization (WHO) Classification of Tumours of Endocrine Organs introduced a new variant of follicular thyroid carcinoma (FTC). It is characterized by a “glomeruloid” architectural pattern of growth. We present a case of follicular tumor with glomeruloid features, with Alcian Blue positive mucinous stromal degeneration in foci of questionable capsular microinvasion. At our knowledge, this the second case of glomeruloid follicular tumor in the literature and the first case in which Alcian Blue staining was used to investigate capsular invasion. Moreover, RAS mutation further supports that this is a variant of follicular tumor with uncertain malignant potential. Hindawi 2021-03-11 /pmc/articles/PMC8016592/ /pubmed/33833889 http://dx.doi.org/10.1155/2021/1686025 Text en Copyright © 2021 Daniela Cabibi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Cabibi, Daniela
Mondello, Andrea
Florena, Ada Maria
Rimi, Giulia
Giannone, Antonino Giulio
Cipolla, Calogero
Valerio, Maria Rosaria
Graceffa, Giuseppa
A Case of Follicular Tumor of Uncertain Malignant Potential (FT-UMP) with Glomeruloid Features Showing Capsular Mucinous Degeneration
title A Case of Follicular Tumor of Uncertain Malignant Potential (FT-UMP) with Glomeruloid Features Showing Capsular Mucinous Degeneration
title_full A Case of Follicular Tumor of Uncertain Malignant Potential (FT-UMP) with Glomeruloid Features Showing Capsular Mucinous Degeneration
title_fullStr A Case of Follicular Tumor of Uncertain Malignant Potential (FT-UMP) with Glomeruloid Features Showing Capsular Mucinous Degeneration
title_full_unstemmed A Case of Follicular Tumor of Uncertain Malignant Potential (FT-UMP) with Glomeruloid Features Showing Capsular Mucinous Degeneration
title_short A Case of Follicular Tumor of Uncertain Malignant Potential (FT-UMP) with Glomeruloid Features Showing Capsular Mucinous Degeneration
title_sort case of follicular tumor of uncertain malignant potential (ft-ump) with glomeruloid features showing capsular mucinous degeneration
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016592/
https://www.ncbi.nlm.nih.gov/pubmed/33833889
http://dx.doi.org/10.1155/2021/1686025
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