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Farnesoid X receptor promotes renal ischaemia‐reperfusion injury by inducing tubular epithelial cell apoptosis

PURPOSE: We investigated the role of farnesoid X receptor (FXR), a ligand‐dependent transcription factor, in renal ischaemia‐reperfusion (I/R) injury. MATERIALS AND METHODS: We performed unilateral renal I/R model in FXR knockout (Fxr(−/−)) and wild‐type (WT) mice in vivo and a hypoxia‐reoxygenation...

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Detalles Bibliográficos
Autores principales:	Xu, Yao, Li, Dawei, Wu, Jiajin, Zhang, Minfang, Shao, Xinghua, Xu, Longmei, Tang, Lumin, Zhu, Minyan, Ni, Zhaohui, Zhang, Ming, Mou, Shan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016637/ https://www.ncbi.nlm.nih.gov/pubmed/33594777 http://dx.doi.org/10.1111/cpr.13005

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