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Epac: new emerging cAMP-binding protein

The well-known second messenger cyclic adenosine monophosphate (cAMP) regulates the morphology and physiology of neurons and thus higher cognitive brain functions. The discovery of exchange protein activated by cAMP (Epac) as a guanine nucleotide exchange factor for Rap GTPases has shed light on pro...

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Detalles Bibliográficos
Autor principal: Lee, Kyungmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016657/
https://www.ncbi.nlm.nih.gov/pubmed/33298248
http://dx.doi.org/10.5483/BMBRep.2021.54.3.233
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author Lee, Kyungmin
author_facet Lee, Kyungmin
author_sort Lee, Kyungmin
collection PubMed
description The well-known second messenger cyclic adenosine monophosphate (cAMP) regulates the morphology and physiology of neurons and thus higher cognitive brain functions. The discovery of exchange protein activated by cAMP (Epac) as a guanine nucleotide exchange factor for Rap GTPases has shed light on protein kinase A (PKA)-independent functions of cAMP signaling in neural tissues. Studies of cAMP-Epac-mediated signaling in neurons under normal and disease conditions also revealed its diverse contributions to neurodevelopment, synaptic remodeling, and neurotransmitter release, as well as learning, memory, and emotion. In this mini-review, the various roles of Epac isoforms, including Epac1 and Epac2, highly expressed in neural tissues are summarized, and controversies or issues are highlighted that need to be resolved to uncover the critical functions of Epac in neural tissues and the potential for a new therapeutic target of mental disorders.
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spelling pubmed-80166572021-04-14 Epac: new emerging cAMP-binding protein Lee, Kyungmin BMB Rep Invited Mini Review The well-known second messenger cyclic adenosine monophosphate (cAMP) regulates the morphology and physiology of neurons and thus higher cognitive brain functions. The discovery of exchange protein activated by cAMP (Epac) as a guanine nucleotide exchange factor for Rap GTPases has shed light on protein kinase A (PKA)-independent functions of cAMP signaling in neural tissues. Studies of cAMP-Epac-mediated signaling in neurons under normal and disease conditions also revealed its diverse contributions to neurodevelopment, synaptic remodeling, and neurotransmitter release, as well as learning, memory, and emotion. In this mini-review, the various roles of Epac isoforms, including Epac1 and Epac2, highly expressed in neural tissues are summarized, and controversies or issues are highlighted that need to be resolved to uncover the critical functions of Epac in neural tissues and the potential for a new therapeutic target of mental disorders. Korean Society for Biochemistry and Molecular Biology 2021-03-31 2021-03-31 /pmc/articles/PMC8016657/ /pubmed/33298248 http://dx.doi.org/10.5483/BMBRep.2021.54.3.233 Text en Copyright © 2021 by the The Korean Society for Biochemistry and Molecular Biology This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Mini Review
Lee, Kyungmin
Epac: new emerging cAMP-binding protein
title Epac: new emerging cAMP-binding protein
title_full Epac: new emerging cAMP-binding protein
title_fullStr Epac: new emerging cAMP-binding protein
title_full_unstemmed Epac: new emerging cAMP-binding protein
title_short Epac: new emerging cAMP-binding protein
title_sort epac: new emerging camp-binding protein
topic Invited Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016657/
https://www.ncbi.nlm.nih.gov/pubmed/33298248
http://dx.doi.org/10.5483/BMBRep.2021.54.3.233
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