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Recurrent hepatogastric fistula during lenvatinib therapy for advanced hepatocellular carcinoma managed by over-the-scope clip closure: a case report
Objective: Lenvatinib is an oral multitarget tyrosine kinase inhibitor (mTKI) and is recommended for patients with advanced hepatocellular carcinoma (HCC) with Child-Pugh A liver function, who are not amenable to surgical resection, locoregional treatment, or transcatheter arterial chemoembolization...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Association of Rural Medicine
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016677/ https://www.ncbi.nlm.nih.gov/pubmed/33833836 http://dx.doi.org/10.2185/jrm.2020-044 |
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author | Miwa, Takao Kochi, Takahiro Watanabe, Keitaro Hanai, Tatsunori Imai, Kenji Suetsugu, Atsushi Takai, Koji Shiraki, Makoto Katsumura, Naoki Shimizu, Masahito |
author_facet | Miwa, Takao Kochi, Takahiro Watanabe, Keitaro Hanai, Tatsunori Imai, Kenji Suetsugu, Atsushi Takai, Koji Shiraki, Makoto Katsumura, Naoki Shimizu, Masahito |
author_sort | Miwa, Takao |
collection | PubMed |
description | Objective: Lenvatinib is an oral multitarget tyrosine kinase inhibitor (mTKI) and is recommended for patients with advanced hepatocellular carcinoma (HCC) with Child-Pugh A liver function, who are not amenable to surgical resection, locoregional treatment, or transcatheter arterial chemoembolization. Hepatogastric fistula is a rare complication with a poor prognosis in patients with HCC. Previous reports on fistula formation during mTKI therapy for HCC were all associated with sorafenib. Here, we report the first case of recurrent hepatogastric fistula during lenvatinib therapy for advanced HCC managed using an over-the-scope clip (OTSC). Patient: We present the case of a 73-year-old man with alcoholic liver cirrhosis who was treated for multiple HCC for 7 years. HCC was treated using repetitive transcatheter arterial chemoembolization, radiofrequency ablation, and sorafenib. Owing to disease progression, lenvatinib treatment was started. During lenvatinib treatment, recurrent hepatogastric fistulas developed. An OTSC was useful for fistula closure and prevention of recurrence. Results: The major cause of fistula formation is considered to be the direct invasion of HCC; however, HCC treatment might also be a contributing factor in our case. In addition, OTSC was useful for fistula closure. Conclusion: Clinicians should be aware of the fatal complications during HCC treatment. |
format | Online Article Text |
id | pubmed-8016677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Japanese Association of Rural Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-80166772021-04-07 Recurrent hepatogastric fistula during lenvatinib therapy for advanced hepatocellular carcinoma managed by over-the-scope clip closure: a case report Miwa, Takao Kochi, Takahiro Watanabe, Keitaro Hanai, Tatsunori Imai, Kenji Suetsugu, Atsushi Takai, Koji Shiraki, Makoto Katsumura, Naoki Shimizu, Masahito J Rural Med Case Report Objective: Lenvatinib is an oral multitarget tyrosine kinase inhibitor (mTKI) and is recommended for patients with advanced hepatocellular carcinoma (HCC) with Child-Pugh A liver function, who are not amenable to surgical resection, locoregional treatment, or transcatheter arterial chemoembolization. Hepatogastric fistula is a rare complication with a poor prognosis in patients with HCC. Previous reports on fistula formation during mTKI therapy for HCC were all associated with sorafenib. Here, we report the first case of recurrent hepatogastric fistula during lenvatinib therapy for advanced HCC managed using an over-the-scope clip (OTSC). Patient: We present the case of a 73-year-old man with alcoholic liver cirrhosis who was treated for multiple HCC for 7 years. HCC was treated using repetitive transcatheter arterial chemoembolization, radiofrequency ablation, and sorafenib. Owing to disease progression, lenvatinib treatment was started. During lenvatinib treatment, recurrent hepatogastric fistulas developed. An OTSC was useful for fistula closure and prevention of recurrence. Results: The major cause of fistula formation is considered to be the direct invasion of HCC; however, HCC treatment might also be a contributing factor in our case. In addition, OTSC was useful for fistula closure. Conclusion: Clinicians should be aware of the fatal complications during HCC treatment. The Japanese Association of Rural Medicine 2021-04-01 2021-04 /pmc/articles/PMC8016677/ /pubmed/33833836 http://dx.doi.org/10.2185/jrm.2020-044 Text en ©2021 The Japanese Association of Rural Medicine This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Miwa, Takao Kochi, Takahiro Watanabe, Keitaro Hanai, Tatsunori Imai, Kenji Suetsugu, Atsushi Takai, Koji Shiraki, Makoto Katsumura, Naoki Shimizu, Masahito Recurrent hepatogastric fistula during lenvatinib therapy for advanced hepatocellular carcinoma managed by over-the-scope clip closure: a case report |
title | Recurrent hepatogastric fistula during lenvatinib therapy for advanced
hepatocellular carcinoma managed by over-the-scope clip closure: a case
report |
title_full | Recurrent hepatogastric fistula during lenvatinib therapy for advanced
hepatocellular carcinoma managed by over-the-scope clip closure: a case
report |
title_fullStr | Recurrent hepatogastric fistula during lenvatinib therapy for advanced
hepatocellular carcinoma managed by over-the-scope clip closure: a case
report |
title_full_unstemmed | Recurrent hepatogastric fistula during lenvatinib therapy for advanced
hepatocellular carcinoma managed by over-the-scope clip closure: a case
report |
title_short | Recurrent hepatogastric fistula during lenvatinib therapy for advanced
hepatocellular carcinoma managed by over-the-scope clip closure: a case
report |
title_sort | recurrent hepatogastric fistula during lenvatinib therapy for advanced
hepatocellular carcinoma managed by over-the-scope clip closure: a case
report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016677/ https://www.ncbi.nlm.nih.gov/pubmed/33833836 http://dx.doi.org/10.2185/jrm.2020-044 |
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