Cargando…

Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons

The spinal cord is a fascinating structure responsible for coordinating movement in vertebrates. Spinal motor neurons control muscle activity by transmitting signals from the spinal cord to diverse peripheral targets. We profiled 43,890 single-nucleus transcriptomes from the adult mouse spinal cord...

Descripción completa

Detalles Bibliográficos
Autores principales:	Blum, Jacob A., Klemm, Sandy, Shadrach, Jennifer L., Guttenplan, Kevin A., Nakayama, Lisa, Kathiria, Arwa, Hoang, Phuong T., Gautier, Olivia, Kaltschmidt, Julia A., Greenleaf, William J., Gitler, Aaron D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016743/ https://www.ncbi.nlm.nih.gov/pubmed/33589834 http://dx.doi.org/10.1038/s41593-020-00795-0

Ejemplares similares

Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model
por: Guttenplan, Kevin A., et al.
Publicado: (2020)

Single-cell epigenomic variability reveals functional cancer heterogeneity
por: Litzenburger, Ulrike M., et al.
Publicado: (2017)

Editorial: Advances in Spinal Cord Epidural Stimulation for Motor and Autonomic Functions Recovery After Severe Spinal Cord Injury
por: Rejc, Enrico, et al.
Publicado: (2022)

An Autonomic Neuroprosthesis: Noninvasive Electrical Spinal Cord Stimulation Restores Autonomic Cardiovascular Function in Individuals with Spinal Cord Injury
por: Phillips, Aaron A., et al.
Publicado: (2018)

A molecular atlas of adult C. elegans motor neurons reveals ancient diversity delineated by conserved transcription factor codes
por: Smith, Jayson J., et al.
Publicado: (2023)

Epidural Spinal Cord Stimulation Facilitates Immediate Restoration of Dormant Motor and Autonomic Supraspinal Pathways after Chronic Neurologically Complete Spinal Cord Injury
por: Darrow, David, et al.
Publicado: (2019)

An optimized ATAC-seq protocol for genome-wide mapping of active regulatory elements in primary mouse cortical neurons
por: Maor-Nof, Maya, et al.
Publicado: (2021)

Semaphorin3A Signaling Is Dispensable for Motor Axon Reinnervation of the Adult Neuromuscular Junction
por: Shadrach, Jennifer L., et al.
Publicado: (2018)

Autonomous optimization of neuroprosthetic stimulation parameters that drive the motor cortex and spinal cord outputs in rats and monkeys
por: Bonizzato, Marco, et al.
Publicado: (2023)

Spinal cord epidural stimulation for motor and autonomic function recovery after chronic spinal cord injury: A case series and technical note
por: Boakye, Maxwell, et al.
Publicado: (2023)

Commissural axon guidance in the developing spinal cord: from Cajal to the present day
por: Comer, J. D., et al.
Publicado: (2019)

Transcription Factor NF-κB Is Transported to the Nucleus via Cytoplasmic Dynein/Dynactin Motor Complex in Hippocampal Neurons
por: Mikenberg, Ilja, et al.
Publicado: (2007)

Prohibitin 1 Modulates Mitochondrial Stress-Related Autophagy in Human Colonic Epithelial Cells
por: Kathiria, Arwa S., et al.
Publicado: (2012)

Autonomic Dysreflexia following Spinal Cord Injury
por: Balik, Vladimír, et al.
Publicado: (2022)

Astrocytes and microglia: Models and tools
por: Guttenplan, Kevin A., et al.
Publicado: (2019)

FLNA-filaminopathy skeletal phenotypes are not due to an osteoblast autonomous loss-of-function
por: Wade, Emma M., et al.
Publicado: (2023)

Heart and Skeletal Muscles: Linked by Autonomic Nervous System
por: Araujo, Claudio Gil, et al.
Publicado: (2019)

Autonomic nervous system correlates in movement observation and motor imagery
por: Collet, C., et al.
Publicado: (2013)

Single cardiac ventricular myosins are autonomous motors
por: Wang, Yihua, et al.
Publicado: (2018)

Prazosin: a potential new management tool for iatrogenic autonomic dysreflexia in individuals with spinal cord injury?
por: Zheng, Mei M.Z., et al.
Publicado: (2015)

Loss of CREST leads to neuroinflammatory responses and ALS-like motor defects in mice
por: Cheng, Cheng, et al.
Publicado: (2019)

The languages of logic : an introduction to formal logic /
por: Guttenplan, Samuel D.
Publicado: (1997)

High-throughput chromatin accessibility profiling at single-cell resolution
por: Mezger, Anja, et al.
Publicado: (2018)

Corticospinal tract insult alters GABAergic circuitry in the mammalian spinal cord
por: Russ, Jeffrey B., et al.
Publicado: (2013)

Motor and autonomic concomitant health improvements with neuromodulation and exercise (MACHINE) training: a randomised controlled trial in individuals with spinal cord injury
por: Shackleton, Claire, et al.
Publicado: (2023)

Cell‐autonomous defects contribute to insulin resistance in skeletal muscle
por: Fujita, Yoshihito, et al.
Publicado: (2021)

Acute Autonomic, Sensory and Motor Neuropathy Associated with Meningoencephalitis
por: Kinoshita, Satoko, et al.
Publicado: (2009)

Skeletal muscle and motor deficits in Neurofibromatosis Type 1
por: Summers, M.A., et al.
Publicado: (2015)

Motor neurobiology of the spinal cord /
Publicado: (2001)

Translatomic analysis of regenerating and degenerating spinal motor neurons in injury and ALS
por: Shadrach, Jennifer L., et al.
Publicado: (2021)

Surgical Treatment of the Motor-Skeletal System
Publicado: (1947)

It's all starting to come together
por: Becker, Lindsay A, et al.
Publicado: (2015)

How AI’s Self-Prolongation Influences People’s Perceptions of Its Autonomous Mind: The Case of U.S. Residents
por: Vuong, Quan-Hoang, et al.
Publicado: (2023)

A systemic increase in the recombination frequency upon local infection of Arabidopsis thaliana plants with oilseed rape mosaic virus depends on plant age, the initial inoculum concentration and the time for virus replication
por: Yao, Youli, et al.
Publicado: (2013)

Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond
por: Luzhna, Lidiya, et al.
Publicado: (2013)

Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2
por: Kim, Garam, et al.
Publicado: (2022)

Autonomic Dysreflexia Resulting in Seizure After Colonoscopy in a Patient With Spinal Cord Injury
por: Fausel, Rebecca A., et al.
Publicado: (2014)

ROS-Based Autonomous Navigation Robot Platform with Stepping Motor
por: Zhao, Shengmin, et al.
Publicado: (2023)

Spinal Cord Injury and Autonomic Dysreflexia: A Case Report on an Overlooked Complication of Spinal Cord Injury
por: Alwashmi, Ahmad H
Publicado: (2022)

Spinal Cord Stimulation Prevents Autonomic Dysreflexia in Individuals with Spinal Cord Injury: A Case Series
por: Samejima, Soshi, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_l8edh9u6gom2qscoapbedddppm