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Transcriptional perturbation of protein arginine methyltransferase-5 exhibits MTAP-selective oncosuppression

We hypothesized that small molecule transcriptional perturbation could be harnessed to target a cellular dependency involving protein arginine methyltransferase 5 (PRMT5) in the context of methylthioadenosine phosphorylase (MTAP) deletion, seen frequently in malignant pleural mesothelioma (MPM). Her...

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Detalles Bibliográficos
Autores principales:	Busacca, Sara, Zhang, Qi, Sharkey, Annabel, Dawson, Alan G., Moore, David A., Waller, David A., Nakas, Apostolos, Jones, Carolyn, Cain, Kelvin, Luo, Jin-li, Salcedo, Adriana, Salaroglio, Iris Chiara, Riganti, Chiara, Le Quesne, John, John, Tom, Boutros, Paul C., Zhang, Shu-Dong, Fennell, Dean A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016828/ https://www.ncbi.nlm.nih.gov/pubmed/33795785 http://dx.doi.org/10.1038/s41598-021-86834-7

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