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A decrease in NAD(+) contributes to the loss of osteoprogenitors and bone mass with aging

Age-related osteoporosis is caused by a deficit in osteoblasts, the cells that secrete bone matrix. The number of osteoblast progenitors also declines with age associated with increased markers of cell senescence. The forkhead box O (FoxO) transcription factors attenuate Wnt/β-catenin signaling and...

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Detalles Bibliográficos
Autores principales:	Kim, Ha-Neui, Ponte, Filipa, Warren, Aaron, Ring, Rebecca, Iyer, Srividhya, Han, Li, Almeida, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016898/ https://www.ncbi.nlm.nih.gov/pubmed/33795658 http://dx.doi.org/10.1038/s41514-021-00058-7

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