SENP1-mediated deSUMOylation of JAK2 regulates its kinase activity and platinum drug resistance

The JAK2/STAT pathway is hyperactivated in many cancers, and such hyperactivation is associated with a poor clinical prognosis and drug resistance. The mechanism regulating JAK2 activity is complex. Although translocation of JAK2 between nucleus and cytoplasm is an important regulatory mechanism, ho...

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Detalles Bibliográficos
Autores principales: Li, Jing, Wu, Ruiqin, Yung, Mingo M. H., Sun, Jing, Li, Zhuqing, Yang, Hai, Zhang, Yi, Liu, Stephanie S., Cheung, Annie N. Y., Ngan, Hextan Y. S., Braisted, John C., Zheng, Wei, Wei, Huiqiang, Gao, Yingtang, Nemes, Peter, Pei, Huadong, Chan, David W., Li, Yiliang, Zhu, Wenge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016909/
https://www.ncbi.nlm.nih.gov/pubmed/33795649
http://dx.doi.org/10.1038/s41419-021-03635-6

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