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Endoscopic resection is a suitable initial treatment strategy for oxyntic gland adenoma or gastric adenocarcinoma of the fundic gland type
The aim of this study was to reveal the histological features of oxyntic gland adenomas and gastric adenocarcinoma of the fundic-gland type (GA-FG). We retrospectively examined the histological features of 126 lesions of oxyntic gland adenoma and/or GA-FG in 116 patients. The prevalence of oxyntic g...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016920/ https://www.ncbi.nlm.nih.gov/pubmed/33795810 http://dx.doi.org/10.1038/s41598-021-86893-w |
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author | Iwamuro, Masaya Kusumoto, Chiaki Nakagawa, Masahiro Kobayashi, Sayo Yoshioka, Masao Inaba, Tomoki Toyokawa, Tatsuya Hori, Shinichiro Tanaka, Shouichi Matsueda, Kazuhiro Tanaka, Takehiro Okada, Hiroyuki |
author_facet | Iwamuro, Masaya Kusumoto, Chiaki Nakagawa, Masahiro Kobayashi, Sayo Yoshioka, Masao Inaba, Tomoki Toyokawa, Tatsuya Hori, Shinichiro Tanaka, Shouichi Matsueda, Kazuhiro Tanaka, Takehiro Okada, Hiroyuki |
author_sort | Iwamuro, Masaya |
collection | PubMed |
description | The aim of this study was to reveal the histological features of oxyntic gland adenomas and gastric adenocarcinoma of the fundic-gland type (GA-FG). We retrospectively examined the histological features of 126 lesions of oxyntic gland adenoma and/or GA-FG in 116 patients. The prevalence of oxyntic gland adenomas and GA-FG was approximately equal. The majority of the lesions were resected by endoscopic mucosal resection using a diathermic snare (EMR, n = 42) or endoscopic submucosal dissection (ESD, n = 72). Histologically, there were no lesions with invasion at the level of the muscularis propria or deeper, and lymphovascular invasion was present in 1.6%. Of the ESD and EMR specimens, there were no lesions that were positive for vertical margins. Among the eight GA-FG patients with deep (≥ 500 μm) submucosal invasion, six were treated with endoscopic resection alone, and no recurrence was documented. No patients died of the disease during the median follow-up period of 14.5 months. In conclusion, all lesions were confined to the mucosa or submucosa and were negative for vertical margins. Lymphovascular invasion was present in only 1.6% of the patients. Thus, we believe that endoscopic resection is a suitable initial treatment method for oxyntic gland adenoma and GA-FG. |
format | Online Article Text |
id | pubmed-8016920 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-80169202021-04-05 Endoscopic resection is a suitable initial treatment strategy for oxyntic gland adenoma or gastric adenocarcinoma of the fundic gland type Iwamuro, Masaya Kusumoto, Chiaki Nakagawa, Masahiro Kobayashi, Sayo Yoshioka, Masao Inaba, Tomoki Toyokawa, Tatsuya Hori, Shinichiro Tanaka, Shouichi Matsueda, Kazuhiro Tanaka, Takehiro Okada, Hiroyuki Sci Rep Article The aim of this study was to reveal the histological features of oxyntic gland adenomas and gastric adenocarcinoma of the fundic-gland type (GA-FG). We retrospectively examined the histological features of 126 lesions of oxyntic gland adenoma and/or GA-FG in 116 patients. The prevalence of oxyntic gland adenomas and GA-FG was approximately equal. The majority of the lesions were resected by endoscopic mucosal resection using a diathermic snare (EMR, n = 42) or endoscopic submucosal dissection (ESD, n = 72). Histologically, there were no lesions with invasion at the level of the muscularis propria or deeper, and lymphovascular invasion was present in 1.6%. Of the ESD and EMR specimens, there were no lesions that were positive for vertical margins. Among the eight GA-FG patients with deep (≥ 500 μm) submucosal invasion, six were treated with endoscopic resection alone, and no recurrence was documented. No patients died of the disease during the median follow-up period of 14.5 months. In conclusion, all lesions were confined to the mucosa or submucosa and were negative for vertical margins. Lymphovascular invasion was present in only 1.6% of the patients. Thus, we believe that endoscopic resection is a suitable initial treatment method for oxyntic gland adenoma and GA-FG. Nature Publishing Group UK 2021-04-01 /pmc/articles/PMC8016920/ /pubmed/33795810 http://dx.doi.org/10.1038/s41598-021-86893-w Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Iwamuro, Masaya Kusumoto, Chiaki Nakagawa, Masahiro Kobayashi, Sayo Yoshioka, Masao Inaba, Tomoki Toyokawa, Tatsuya Hori, Shinichiro Tanaka, Shouichi Matsueda, Kazuhiro Tanaka, Takehiro Okada, Hiroyuki Endoscopic resection is a suitable initial treatment strategy for oxyntic gland adenoma or gastric adenocarcinoma of the fundic gland type |
title | Endoscopic resection is a suitable initial treatment strategy for oxyntic gland adenoma or gastric adenocarcinoma of the fundic gland type |
title_full | Endoscopic resection is a suitable initial treatment strategy for oxyntic gland adenoma or gastric adenocarcinoma of the fundic gland type |
title_fullStr | Endoscopic resection is a suitable initial treatment strategy for oxyntic gland adenoma or gastric adenocarcinoma of the fundic gland type |
title_full_unstemmed | Endoscopic resection is a suitable initial treatment strategy for oxyntic gland adenoma or gastric adenocarcinoma of the fundic gland type |
title_short | Endoscopic resection is a suitable initial treatment strategy for oxyntic gland adenoma or gastric adenocarcinoma of the fundic gland type |
title_sort | endoscopic resection is a suitable initial treatment strategy for oxyntic gland adenoma or gastric adenocarcinoma of the fundic gland type |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016920/ https://www.ncbi.nlm.nih.gov/pubmed/33795810 http://dx.doi.org/10.1038/s41598-021-86893-w |
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