High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn’s disease-associated Escherichia coli

Adherent-invasive Escherichia coli (AIEC) are pathogenic bacteria frequently isolated from patients who have Crohn’s disease (CD). Despite the phenotypic differences between AIEC and commensal E. coli, comparative genomic approaches have been unable to differentiate these two groups, making the iden...

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Detalles Bibliográficos
Autores principales: Elhenawy, Wael, Hordienko, Sarah, Gould, Steven, Oberc, Alexander M., Tsai, Caressa N., Hubbard, Troy P., Waldor, Matthew K., Coombes, Brian K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016931/
https://www.ncbi.nlm.nih.gov/pubmed/33795670
http://dx.doi.org/10.1038/s41467-021-22306-w

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