Identification of novel inhibitors of Keap1/Nrf2 by a promising method combining protein–protein interaction-oriented library and machine learning

Protein–protein interactions (PPIs) are prospective but challenging targets for drug discovery, because screening using traditional small-molecule libraries often fails to identify hits. Recently, we developed a PPI-oriented library comprising 12,593 small-to-medium-sized newly synthesized molecules...

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Detalles Bibliográficos
Autores principales: Shimizu, Yugo, Yonezawa, Tomoki, Sakamoto, Junichi, Furuya, Toshio, Osawa, Masanori, Ikeda, Kazuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016952/
https://www.ncbi.nlm.nih.gov/pubmed/33795749
http://dx.doi.org/10.1038/s41598-021-86616-1

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