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Baicalin Inhibits Ferroptosis in Intracerebral Hemorrhage

Intracerebral hemorrhage (ICH) is a subtype of stroke characterized by high mortality and disability rates. To date, the exact etiology of ICH-induced brain injury is still unclear. Moreover, there is no effective treatment to delay or prevent disease progression currently. Increasing evidence sugge...

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Autores principales: Duan, Lining, Zhang, Ying, Yang, Yuna, Su, Shiyu, Zhou, Ligui, Lo, Po-Chieh, Cai, Jiaying, Qiao, Yiqi, Li, Min, Huang, Shuiqing, Wang, Hong, Mo, Yousheng, Wang, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017143/
https://www.ncbi.nlm.nih.gov/pubmed/33815110
http://dx.doi.org/10.3389/fphar.2021.629379
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author Duan, Lining
Zhang, Ying
Yang, Yuna
Su, Shiyu
Zhou, Ligui
Lo, Po-Chieh
Cai, Jiaying
Qiao, Yiqi
Li, Min
Huang, Shuiqing
Wang, Hong
Mo, Yousheng
Wang, Qi
author_facet Duan, Lining
Zhang, Ying
Yang, Yuna
Su, Shiyu
Zhou, Ligui
Lo, Po-Chieh
Cai, Jiaying
Qiao, Yiqi
Li, Min
Huang, Shuiqing
Wang, Hong
Mo, Yousheng
Wang, Qi
author_sort Duan, Lining
collection PubMed
description Intracerebral hemorrhage (ICH) is a subtype of stroke characterized by high mortality and disability rates. To date, the exact etiology of ICH-induced brain injury is still unclear. Moreover, there is no effective treatment to delay or prevent disease progression currently. Increasing evidence suggests that ferroptosis plays a dominant role in the pathogenesis of ICH injury. Baicalin is a main active ingredient of Chinese herbal medicine Scutellaria baicalensis. It has been reported to exhibit neuroprotective effects against ICH-induced brain injury as well as reduce iron deposition in multiple tissues. Therefore, in this study, we focused on the protective mechanisms of baicalin against ferroptosis caused by ICH using a hemin-induced in vitro model and a Type IV collagenase-induced in vivo model. Our results revealed that baicalin enhanced cell viability and suppressed ferroptosis in rat pheochromocytoma PC12 cells treated with hemin, erastin and RSL3. Importantly, baicalin showed anti-ferroptosis effect on primary cortical neurons (PCN). Furthermore, baicalin alleviated motor deficits and brain injury in ICH model mice through inhibiting ferroptosis. Additionally, baicalin existed no obvious toxicity towards the liver and kidney of mice. Evidently, ferroptosis is a key pathological feature of ICH and baicalin can prevent the development of ferroptosis in ICH. As such, baicalin is a potential therapeutic drug for ICH treatment.
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spelling pubmed-80171432021-04-03 Baicalin Inhibits Ferroptosis in Intracerebral Hemorrhage Duan, Lining Zhang, Ying Yang, Yuna Su, Shiyu Zhou, Ligui Lo, Po-Chieh Cai, Jiaying Qiao, Yiqi Li, Min Huang, Shuiqing Wang, Hong Mo, Yousheng Wang, Qi Front Pharmacol Pharmacology Intracerebral hemorrhage (ICH) is a subtype of stroke characterized by high mortality and disability rates. To date, the exact etiology of ICH-induced brain injury is still unclear. Moreover, there is no effective treatment to delay or prevent disease progression currently. Increasing evidence suggests that ferroptosis plays a dominant role in the pathogenesis of ICH injury. Baicalin is a main active ingredient of Chinese herbal medicine Scutellaria baicalensis. It has been reported to exhibit neuroprotective effects against ICH-induced brain injury as well as reduce iron deposition in multiple tissues. Therefore, in this study, we focused on the protective mechanisms of baicalin against ferroptosis caused by ICH using a hemin-induced in vitro model and a Type IV collagenase-induced in vivo model. Our results revealed that baicalin enhanced cell viability and suppressed ferroptosis in rat pheochromocytoma PC12 cells treated with hemin, erastin and RSL3. Importantly, baicalin showed anti-ferroptosis effect on primary cortical neurons (PCN). Furthermore, baicalin alleviated motor deficits and brain injury in ICH model mice through inhibiting ferroptosis. Additionally, baicalin existed no obvious toxicity towards the liver and kidney of mice. Evidently, ferroptosis is a key pathological feature of ICH and baicalin can prevent the development of ferroptosis in ICH. As such, baicalin is a potential therapeutic drug for ICH treatment. Frontiers Media S.A. 2021-03-19 /pmc/articles/PMC8017143/ /pubmed/33815110 http://dx.doi.org/10.3389/fphar.2021.629379 Text en Copyright © 2021 Duan, Zhang, Yang, Su, Zhou, Lo, Cai, Qiao, Li, Huang, Wang, Mo and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Duan, Lining
Zhang, Ying
Yang, Yuna
Su, Shiyu
Zhou, Ligui
Lo, Po-Chieh
Cai, Jiaying
Qiao, Yiqi
Li, Min
Huang, Shuiqing
Wang, Hong
Mo, Yousheng
Wang, Qi
Baicalin Inhibits Ferroptosis in Intracerebral Hemorrhage
title Baicalin Inhibits Ferroptosis in Intracerebral Hemorrhage
title_full Baicalin Inhibits Ferroptosis in Intracerebral Hemorrhage
title_fullStr Baicalin Inhibits Ferroptosis in Intracerebral Hemorrhage
title_full_unstemmed Baicalin Inhibits Ferroptosis in Intracerebral Hemorrhage
title_short Baicalin Inhibits Ferroptosis in Intracerebral Hemorrhage
title_sort baicalin inhibits ferroptosis in intracerebral hemorrhage
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017143/
https://www.ncbi.nlm.nih.gov/pubmed/33815110
http://dx.doi.org/10.3389/fphar.2021.629379
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