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Mice Heterozygous for the Sodium Channel Scn8a (Nav1.6) Have Reduced Inflammatory Responses During EAE and Following LPS Challenge

Voltage gated sodium (Nav) channels contribute to axonal damage following demyelination in experimental autoimmune encephalomyelitis (EAE), a rodent model of multiple sclerosis (MS). The Nav1.6 isoform has been implicated as a primary contributor in this process. However, the role of Nav1.6 in immun...

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Detalles Bibliográficos
Autores principales:	Alrashdi, Barakat, Dawod, Bassel, Tacke, Sabine, Kuerten, Stefanie, Côté, Patrice D., Marshall, Jean S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017164/ https://www.ncbi.nlm.nih.gov/pubmed/33815353 http://dx.doi.org/10.3389/fimmu.2021.533423

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