Cargando…

Tau: A Signaling Hub Protein

Over four decades ago, in vitro experiments showed that tau protein interacts with and stabilizes microtubules in a phosphorylation-dependent manner. This observation fueled the widespread hypotheses that these properties extend to living neurons and that reduced stability of microtubules represents...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mueller, Rebecca L., Combs, Benjamin, Alhadidy, Mohammed M., Brady, Scott T., Morfini, Gerardo A., Kanaan, Nicholas M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017207/ https://www.ncbi.nlm.nih.gov/pubmed/33815057 http://dx.doi.org/10.3389/fnmol.2021.647054

Ejemplares similares

Frontotemporal Lobar Dementia Mutant Tau Impairs Axonal Transport through a Protein Phosphatase 1γ-Dependent Mechanism
por: Combs, Benjamin, et al.
Publicado: (2021)

Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms
por: Kneynsberg, Andrew, et al.
Publicado: (2017)

Defined Tau Phosphospecies Differentially Inhibit Fast Axonal Transport Through Activation of Two Independent Signaling Pathways
por: Morris, Sarah L., et al.
Publicado: (2021)

Neuronal and Glial Distribution of Tau Protein in the Adult Rat and Monkey
por: Kanaan, Nicholas M., et al.
Publicado: (2021)

Engagement of Neurotropic Viruses in Fast Axonal Transport: Mechanisms, Potential Role of Host Kinases and Implications for Neuronal Dysfunction
por: Richards, Alexsia, et al.
Publicado: (2021)

Liquid-liquid phase separation induces pathogenic tau conformations in vitro
por: Kanaan, Nicholas M., et al.
Publicado: (2020)

Pathological conformations involving the amino terminus of tau occur early in Alzheimer’s disease and are differentially detected by monoclonal antibodies
por: Combs, Benjamin, et al.
Publicado: (2016)

Editorial: Kinase/phosphatase signaling and axonal function in health and disease
por: Morfini, Gerardo, et al.
Publicado: (2023)

EFhd2 Affects Tau Liquid–Liquid Phase Separation
por: Vega, Irving E., et al.
Publicado: (2019)

Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse
por: Benskey, Matthew J., et al.
Publicado: (2023)

Phosphoregulation of Tau modulates inhibition of kinesin-1 motility
por: Stern, Jamie L., et al.
Publicado: (2017)

Cortical Hub for Flavor Sensation in Rodents
por: Samuelsen, Chad L., et al.
Publicado: (2021)

The Hub-and-Spoke Management of Glaucoma
por: Nuzzi, Raffaele, et al.
Publicado: (2020)

Aging Does Not Affect Axon Initial Segment Structure and Somatic Localization of Tau Protein in Hippocampal Neurons of Fischer 344 Rats
por: Kneynsberg, Andrew, et al.
Publicado: (2017)

Internalization and Axonal Transport of the HIV Glycoprotein gp120
por: Berth, Sarah, et al.
Publicado: (2015)

Tau Protein and Adult Hippocampal Neurogenesis
por: Fuster-Matanzo, Almudena, et al.
Publicado: (2012)

Axon-Autonomous Effects of the Amyloid Precursor Protein Intracellular Domain (AICD) on Kinase Signaling and Fast Axonal Transport
por: König, Svenja, et al.
Publicado: (2023)

HIV Glycoprotein Gp120 Impairs Fast Axonal Transport by Activating Tak1 Signaling Pathways
por: Berth, Sarah H., et al.
Publicado: (2016)

Functional Connectivity Hubs and Networks in the Awake Marmoset Brain
por: Belcher, Annabelle M., et al.
Publicado: (2016)

Enhanced Tau Protein Translation by Hyper-Excitation
por: Kobayashi, Shunsuke, et al.
Publicado: (2019)

Novel Non-phosphorylated Serine 9/21 GSK3β/α Antibodies: Expanding the Tools for Studying GSK3 Regulation
por: Grabinski, Tessa, et al.
Publicado: (2016)

Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis
por: Hu, Wen, et al.
Publicado: (2017)

Proteomic Dissection of Nanotopography-Sensitive Mechanotransductive Signaling Hubs that Foster Neuronal Differentiation in PC12 Cells
por: Maffioli, Elisa, et al.
Publicado: (2018)

What Renders TAU Toxic
por: Götz, Jürgen, et al.
Publicado: (2013)

Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage
por: Shafiei, Scott S., et al.
Publicado: (2017)

Neuropsychological evidence of multi-domain network hubs in the human thalamus
por: Hwang, Kai, et al.
Publicado: (2021)

Biochemical Distribution of Tau Protein in Synaptosomal Fraction of Transgenic Mice Expressing Human P301L Tau
por: Sahara, Naruhiko, et al.
Publicado: (2014)

Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain
por: DeVos, Sarah L., et al.
Publicado: (2018)

Tau Structures
por: Avila, Jesus, et al.
Publicado: (2016)

New Insights Into Drug Discovery Targeting Tau Protein
por: Soeda, Yoshiyuki, et al.
Publicado: (2020)

Tau-Cofactor Complexes as Building Blocks of Tau Fibrils
por: Fichou, Yann, et al.
Publicado: (2019)

Talin as a mechanosensitive signaling hub
por: Goult, Benjamin T., et al.
Publicado: (2018)

Role of Tau Protein in Remodeling of Circadian Neuronal Circuits and Sleep
por: Arnes, Mercedes, et al.
Publicado: (2019)

The AII amacrine cell connectome: a dense network hub
por: Marc, Robert E., et al.
Publicado: (2014)

Astrocytic Propagation of Tau in the Context of Alzheimer's Disease
por: Fleeman, Rebecca M., et al.
Publicado: (2021)

Pathological Human Tau Induces Alterations in the Brain Insulin Signaling Cascade
por: El Idrissi, Abdeslem, et al.
Publicado: (2022)

Functional connectivity MRI quality control procedures in CONN
por: Morfini, Francesca, et al.
Publicado: (2023)

Mapping Multiplex Hubs in Human Functional Brain Networks
por: De Domenico, Manlio, et al.
Publicado: (2016)

Uncovering the Transcriptional Correlates of Hub Connectivity in Neural Networks
por: Arnatkevičiūtė, Aurina, et al.
Publicado: (2019)

Tau Protein and Its Role in Blood–Brain Barrier Dysfunction
por: Michalicova, Alena, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_km911qc59j89ttg4emsdasj5oh