CXCL12-CXCR4-Mediated Chemotaxis Supports Accumulation of Mucosal-Associated Invariant T Cells Into the Liver of Patients With PBC

Objectives: To explore the potential role of CD3(+)CD8(+)CD161(high) TCRVα7.2(+) mucosal-associated invariant T (MAIT) cells in the pathogenesis of primary biliary cholangitis (PBC). Methods: We enrolled 55 patients with PBC, 69 healthy controls (HCs), and 8 patients with hepatic hemangioma. Circula...

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Detalles Bibliográficos
Autores principales: Chen, Zhilei, Liu, Suying, He, Chengmei, Sun, Jinlei, Wang, Li, Chen, Hua, Zhang, Fengchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017208/
https://www.ncbi.nlm.nih.gov/pubmed/33815355
http://dx.doi.org/10.3389/fimmu.2021.578548

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