Engineered CRISPR/Cas13d Sensing hTERT Selectively Inhibits the Progression of Bladder Cancer In Vitro

Aptazyme and CRISPR/Cas gene editing system were widely used for regulating gene expression in various diseases, including cancer. This work aimed to reconstruct CRISPR/Cas13d tool for sensing hTERT exclusively based on the new device OFF-switch hTERT aptazyme that was inserted into the 3’ UTR of th...

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Detalles Bibliográficos
Autores principales: Zhuang, Chengle, Zhuang, Changshui, Zhou, Qun, Huang, Xueting, Gui, Yaoting, Lai, Yongqing, Yang, Shangqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017217/
https://www.ncbi.nlm.nih.gov/pubmed/33816560
http://dx.doi.org/10.3389/fmolb.2021.646412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017217/
https://www.ncbi.nlm.nih.gov/pubmed/33816560
http://dx.doi.org/10.3389/fmolb.2021.646412

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