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Engineered CRISPR/Cas13d Sensing hTERT Selectively Inhibits the Progression of Bladder Cancer In Vitro

Aptazyme and CRISPR/Cas gene editing system were widely used for regulating gene expression in various diseases, including cancer. This work aimed to reconstruct CRISPR/Cas13d tool for sensing hTERT exclusively based on the new device OFF-switch hTERT aptazyme that was inserted into the 3’ UTR of th...

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Detalles Bibliográficos
Autores principales:	Zhuang, Chengle, Zhuang, Changshui, Zhou, Qun, Huang, Xueting, Gui, Yaoting, Lai, Yongqing, Yang, Shangqi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017217/ https://www.ncbi.nlm.nih.gov/pubmed/33816560 http://dx.doi.org/10.3389/fmolb.2021.646412

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