Impact of the Epithelial Lining Fluid Milieu on Amikacin Pharmacodynamics Against Pseudomonas aeruginosa

BACKGROUND: Even though nebulised administration of amikacin can achieve high epithelial lining fluid concentrations, this has not translated into improved patient outcomes in clinical trials. One possible reason is that the cellular and chemical composition of the epithelial lining fluid may inhibi...

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Detalles Bibliográficos
Autores principales: Heffernan, Aaron J., Sime, Fekade B., Lim, Sazlyna Mohd Sazlly, Naicker, Saiyuri, Andrews, Katherine T., Ellwood, David, Lipman, Jeffrey, Grimwood, Keith, Roberts, Jason A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017437/
https://www.ncbi.nlm.nih.gov/pubmed/33797739
http://dx.doi.org/10.1007/s40268-021-00344-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017437/
https://www.ncbi.nlm.nih.gov/pubmed/33797739
http://dx.doi.org/10.1007/s40268-021-00344-5

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