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Impact of the Epithelial Lining Fluid Milieu on Amikacin Pharmacodynamics Against Pseudomonas aeruginosa
BACKGROUND: Even though nebulised administration of amikacin can achieve high epithelial lining fluid concentrations, this has not translated into improved patient outcomes in clinical trials. One possible reason is that the cellular and chemical composition of the epithelial lining fluid may inhibi...
Autores principales: | Heffernan, Aaron J., Sime, Fekade B., Lim, Sazlyna Mohd Sazlly, Naicker, Saiyuri, Andrews, Katherine T., Ellwood, David, Lipman, Jeffrey, Grimwood, Keith, Roberts, Jason A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017437/ https://www.ncbi.nlm.nih.gov/pubmed/33797739 http://dx.doi.org/10.1007/s40268-021-00344-5 |
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