Src is essential for the endosomal delivery of the FGFR4 signaling complex in hepatocellular carcinoma

BACKGROUND: Hepatocytes usually express fibroblast growth factor receptor 4 (FGFR4), but not its ligand, fibroblast growth factor 19 (FGF19). A subtype of hepatocellular carcinoma (HCC) expresses FGF19, which activates the FGFR4 signaling pathway that induces cell proliferation. FGFR4 inhibitors tha...

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Detalles Bibliográficos
Autores principales: Shin, Ji-Yon, Ahn, Sung-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017611/
https://www.ncbi.nlm.nih.gov/pubmed/33794926
http://dx.doi.org/10.1186/s12967-021-02807-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017611/
https://www.ncbi.nlm.nih.gov/pubmed/33794926
http://dx.doi.org/10.1186/s12967-021-02807-4

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