Cargando…

Src is essential for the endosomal delivery of the FGFR4 signaling complex in hepatocellular carcinoma

BACKGROUND: Hepatocytes usually express fibroblast growth factor receptor 4 (FGFR4), but not its ligand, fibroblast growth factor 19 (FGF19). A subtype of hepatocellular carcinoma (HCC) expresses FGF19, which activates the FGFR4 signaling pathway that induces cell proliferation. FGFR4 inhibitors tha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shin, Ji-Yon, Ahn, Sung-Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017611/ https://www.ncbi.nlm.nih.gov/pubmed/33794926 http://dx.doi.org/10.1186/s12967-021-02807-4

Ejemplares similares

FGF19–FGFR4 Signaling in Hepatocellular Carcinoma
por: Raja, Aroosha, et al.
Publicado: (2019)

FGFR redundancy limits the efficacy of FGFR4-selective inhibitors in hepatocellular carcinoma
por: Tao, Zhanchao, et al.
Publicado: (2022)

Rhenium N-heterocyclic carbene complexes block growth of aggressive cancers by inhibiting FGFR- and SRC-mediated signalling
por: Domenichini, Alice, et al.
Publicado: (2020)

FGF19/FGFR4 signaling contributes to the resistance of hepatocellular carcinoma to sorafenib
por: Gao, Lixia, et al.
Publicado: (2017)

Targeting the Src Pathway Enhances the Efficacy of Selective FGFR Inhibitors in Urothelial Cancers with FGFR3 Alterations
por: Lima, Nadia Carvalho, et al.
Publicado: (2020)

Src in endosomal membranes promotes exosome secretion and tumor progression
por: Hikita, Tomoya, et al.
Publicado: (2019)

FGF/FGFR Signaling in Hepatocellular Carcinoma: From Carcinogenesis to Recent Therapeutic Intervention
por: Wang, Yijun, et al.
Publicado: (2021)

Association of p60c-src with endosomal membranes in mammalian fibroblasts
Publicado: (1992)

The Late Endosome is Essential for mTORC1 Signaling
por: Flinn, Rory J., et al.
Publicado: (2010)

The impact of FGF19/FGFR4 signaling inhibition in antitumor activity of multi-kinase inhibitors in hepatocellular carcinoma
por: Kanzaki, Hiroaki, et al.
Publicado: (2021)

Targeting FGFR4 Inhibits Hepatocellular Carcinoma in Preclinical Mouse Models
por: French, Dorothy M., et al.
Publicado: (2012)

DJ-1/FGFR-1 Signaling Pathway Contributes to Sorafenib Resistance in Hepatocellular Carcinoma
por: Chen, Xin, et al.
Publicado: (2022)

Complexity of FGFR signalling in metastatic urothelial cancer
por: Rodriguez-Vida, Alejo, et al.
Publicado: (2015)

FGFR4 and EZH2 inhibitors synergistically induce hepatocellular carcinoma apoptosis via repressing YAP signaling
por: Yang, Yiqi, et al.
Publicado: (2023)

Delivery of ligands from sorting endosomes to late endosomes occurs by maturation of sorting endosomes
Publicado: (1992)

The Late Endosomal HOPS Complex Anchors Active G-Protein Signaling Essential for Pathogenesis in Magnaporthe oryzae
por: Ramanujam, Ravikrishna, et al.
Publicado: (2013)

Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway
por: Seo, Hye-Young, et al.
Publicado: (2021)

COL4A1 promotes the growth and metastasis of hepatocellular carcinoma cells by activating FAK-Src signaling
por: Wang, Ting, et al.
Publicado: (2020)

IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses
por: Evnouchidou, Irini, et al.
Publicado: (2020)

Endosome signaling
por: Tuma, Rabiya S.
Publicado: (2006)

L1CAM promotes ovarian cancer stemness and tumor initiation via FGFR1/SRC/STAT3 signaling
por: Giordano, Marco, et al.
Publicado: (2021)

Crosstalk between Activated and Inactivated c-Src in Hepatocellular Carcinoma
por: Chen, Mei-Lin, et al.
Publicado: (2011)

FGF19-mediated ELF4 overexpression promotes colorectal cancer metastasis through transactivating FGFR4 and SRC
por: Chen, Xilang, et al.
Publicado: (2023)

A Membrane Coat Complex Essential for Endosome-to-Golgi Retrograde Transport in Yeast
por: Seaman, Matthew N.J., et al.
Publicado: (1998)

FgRab5 and FgRab7 are essential for endosomes biogenesis and non-redundantly recruit the retromer complex to the endosomes in Fusarium graminearum
por: Abubakar, Yakubu Saddeeq, et al.
Publicado: (2021)

Src signaling in a low-complexity unicellular kinome
por: Suga, Hiroshi, et al.
Publicado: (2018)

CD155/SRC complex promotes hepatocellular carcinoma progression via inhibiting the p38 MAPK signalling pathway and correlates with poor prognosis
por: Jin, An‐Li, et al.
Publicado: (2022)

miR-486-3p mediates hepatocellular carcinoma sorafenib resistance by targeting FGFR4 and EGFR
por: Ji, Lin, et al.
Publicado: (2020)

FGFR4 and TGF-β1 Expression in Hepatocellular Carcinoma: Correlation with Clinicopathological Features and Prognosis
por: Chen, Zhixin, et al.
Publicado: (2013)

Targeting FGF19/FGFR4 Pathway: A Novel Therapeutic Strategy for Hepatocellular Carcinoma
por: Repana, Dimitra, et al.
Publicado: (2015)

Genomic Relevance of FGFR2 on the Prognosis of HCV-Induced Hepatocellular Carcinoma Patients
por: Khan, Walizeb, et al.
Publicado: (2022)

BGJ398, A Pan-FGFR Inhibitor, Overcomes Paclitaxel Resistance in Urothelial Carcinoma with FGFR1 Overexpression
por: Kim, Se Hyun, et al.
Publicado: (2018)

Distinct effects of endosomal escape and inhibition of endosomal trafficking on gene delivery via electrotransfection
por: Cervia, Lisa D., et al.
Publicado: (2017)

Drosophila Rab2 controls endosome-lysosome fusion and LAMP delivery to late endosomes
por: Lund, Viktor Karlovich, et al.
Publicado: (2018)

Homeobox B5 promotes metastasis and poor prognosis in Hepatocellular Carcinoma, via FGFR4 and CXCL1 upregulation
por: He, Qin, et al.
Publicado: (2021)

Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB
por: Yang, Chaofeng, et al.
Publicado: (2012)

Paracrine Fibroblast Growth Factor Initiates Oncogenic Synergy with Epithelial FGFR/Src Transformation in Prostate Tumor Progression()()
por: Li, Qianjin, et al.
Publicado: (2018)

FGF/FGFR signaling in health and disease
por: Xie, Yangli, et al.
Publicado: (2020)

Increased c‑SRC expression is involved in acquired resistance to lenvatinib in hepatocellular carcinoma
por: Takahashi, Masamitsu, et al.
Publicado: (2023)

Mutation of the SRC Gene in Endometrial Carcinoma
por: Sugimura, Masaki, et al.
Publicado: (2000)

Cannot write session to /tmp/vufind_sessions/sess_6do3fl16616ucn6eme2gvv65ud