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Oral administration of repurposed drug targeting Cyp46A1 increases survival times of prion infected mice

Prion diseases are fatal, infectious, and incurable neurodegenerative disorders caused by misfolding of the cellular prion protein (PrP(C)) into the infectious isoform (PrP(Sc)). In humans, there are sporadic, genetic and infectious etiologies, with sporadic Creutzfeldt-Jakob disease (sCJD) being th...

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Detalles Bibliográficos
Autores principales:	Ali, Tahir, Hannaoui, Samia, Nemani, Satish, Tahir, Waqas, Zemlyankina, Irina, Cherry, Pearl, Shim, Su Yeon, Sim, Valerie, Schaetzl, Hermann M., Gilch, Sabine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017635/ https://www.ncbi.nlm.nih.gov/pubmed/33795005 http://dx.doi.org/10.1186/s40478-021-01162-1

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