Cargando…
Sole adjuvant intraoperative breast radiotherapy in Taiwan: a single-center experience
INTRODUCTION: Intraoperative radiotherapy (IORT) is more convenient than standard whole breast external beam radiotherapy (EBRT) as a sole adjuvant radiotherapy for breast cancer. The impact of age on breast cancer course and treatment strategy is still under investigation, and the peak age for brea...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017735/ https://www.ncbi.nlm.nih.gov/pubmed/33794958 http://dx.doi.org/10.1186/s13058-021-01421-y |
_version_ | 1783674105236553728 |
---|---|
author | Yang, Hsin-Yi Tu, Chi-Wen Chen, Chien-Chin Lee, Cheng-Yen Hsu, Yu-Chen |
author_facet | Yang, Hsin-Yi Tu, Chi-Wen Chen, Chien-Chin Lee, Cheng-Yen Hsu, Yu-Chen |
author_sort | Yang, Hsin-Yi |
collection | PubMed |
description | INTRODUCTION: Intraoperative radiotherapy (IORT) is more convenient than standard whole breast external beam radiotherapy (EBRT) as a sole adjuvant radiotherapy for breast cancer. The impact of age on breast cancer course and treatment strategy is still under investigation, and the peak age for breast cancer in Taiwan is much younger than that in Western countries. We aimed to review the oncological outcomes of sole IORT compared with standard EBRT in a country with younger breast cancer patients. PATIENTS AND METHODS: We reviewed patients with invasive breast cancer who received breast-conserving surgery (BCS) from September 2014 to December 2016. The clinicopathologic characteristics and oncological outcomes of eligible patients who received EBRT or IORT as sole adjuvant radiotherapy after BCS were collected and reviewed. RESULTS: A total of 170 patients were enrolled with a mean follow-up time of 3.53 ± 0.82 years. The risk of locoregional recurrence was 2.44% for EBRT versus 10.64% for IORT (p = 0.024). IORT was a significant risk factor of locoregional recurrence (p = 0.005). The hazard ratios (HRs) for locoregional recurrence in the IORT group compared with the EBRT group were significantly higher in non-suitable risk group patients (HR = 7.02, p = 0.009) and in patients under 50 years old (HR = 10.42, p = 0.011). CONCLUSIONS: Locoregional recurrence was significantly higher in patients who received IORT than in those who underwent EBRT. IORT should not be used alone in patients under 50 years old who do not belong to a suitable group. |
format | Online Article Text |
id | pubmed-8017735 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-80177352021-04-02 Sole adjuvant intraoperative breast radiotherapy in Taiwan: a single-center experience Yang, Hsin-Yi Tu, Chi-Wen Chen, Chien-Chin Lee, Cheng-Yen Hsu, Yu-Chen Breast Cancer Res Research Article INTRODUCTION: Intraoperative radiotherapy (IORT) is more convenient than standard whole breast external beam radiotherapy (EBRT) as a sole adjuvant radiotherapy for breast cancer. The impact of age on breast cancer course and treatment strategy is still under investigation, and the peak age for breast cancer in Taiwan is much younger than that in Western countries. We aimed to review the oncological outcomes of sole IORT compared with standard EBRT in a country with younger breast cancer patients. PATIENTS AND METHODS: We reviewed patients with invasive breast cancer who received breast-conserving surgery (BCS) from September 2014 to December 2016. The clinicopathologic characteristics and oncological outcomes of eligible patients who received EBRT or IORT as sole adjuvant radiotherapy after BCS were collected and reviewed. RESULTS: A total of 170 patients were enrolled with a mean follow-up time of 3.53 ± 0.82 years. The risk of locoregional recurrence was 2.44% for EBRT versus 10.64% for IORT (p = 0.024). IORT was a significant risk factor of locoregional recurrence (p = 0.005). The hazard ratios (HRs) for locoregional recurrence in the IORT group compared with the EBRT group were significantly higher in non-suitable risk group patients (HR = 7.02, p = 0.009) and in patients under 50 years old (HR = 10.42, p = 0.011). CONCLUSIONS: Locoregional recurrence was significantly higher in patients who received IORT than in those who underwent EBRT. IORT should not be used alone in patients under 50 years old who do not belong to a suitable group. BioMed Central 2021-04-01 2021 /pmc/articles/PMC8017735/ /pubmed/33794958 http://dx.doi.org/10.1186/s13058-021-01421-y Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Yang, Hsin-Yi Tu, Chi-Wen Chen, Chien-Chin Lee, Cheng-Yen Hsu, Yu-Chen Sole adjuvant intraoperative breast radiotherapy in Taiwan: a single-center experience |
title | Sole adjuvant intraoperative breast radiotherapy in Taiwan: a single-center experience |
title_full | Sole adjuvant intraoperative breast radiotherapy in Taiwan: a single-center experience |
title_fullStr | Sole adjuvant intraoperative breast radiotherapy in Taiwan: a single-center experience |
title_full_unstemmed | Sole adjuvant intraoperative breast radiotherapy in Taiwan: a single-center experience |
title_short | Sole adjuvant intraoperative breast radiotherapy in Taiwan: a single-center experience |
title_sort | sole adjuvant intraoperative breast radiotherapy in taiwan: a single-center experience |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017735/ https://www.ncbi.nlm.nih.gov/pubmed/33794958 http://dx.doi.org/10.1186/s13058-021-01421-y |
work_keys_str_mv | AT yanghsinyi soleadjuvantintraoperativebreastradiotherapyintaiwanasinglecenterexperience AT tuchiwen soleadjuvantintraoperativebreastradiotherapyintaiwanasinglecenterexperience AT chenchienchin soleadjuvantintraoperativebreastradiotherapyintaiwanasinglecenterexperience AT leechengyen soleadjuvantintraoperativebreastradiotherapyintaiwanasinglecenterexperience AT hsuyuchen soleadjuvantintraoperativebreastradiotherapyintaiwanasinglecenterexperience |