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ABT-263 enhanced bacterial phagocytosis of macrophages in aged mouse through Beclin-1-dependent autophagy
BACKGROUND: Sepsis is a critical challenge for the older adults as the immune function is less responsive by aging. Although cell numbers seem preserved in the older adults, macrophages present age-related function decline, which including reduced chemokines, phagocytosis, and autophagy. ABT-263, an...
Autores principales: | Zhang, Yu, Tang, Li-hua, Lu, Jia, Xu, Li-ming, Cheng, Bao-li, Xiong, Jun-yu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017763/ https://www.ncbi.nlm.nih.gov/pubmed/33794800 http://dx.doi.org/10.1186/s12877-021-02173-2 |
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