Structural basis for differential recognition of phosphohistidine-containing peptides by 1-pHis and 3-pHis monoclonal antibodies

In 2015, monoclonal antibodies (mAbs) that selectively recognize the 1-pHis or 3-pHis isoforms of phosphohistidine were developed by immunizing rabbits with degenerate Ala/Gly peptides containing the nonhydrolyzable phosphohistidine (pHis) analog- phosphotriazolylalanine (pTza). Here, we report stru...

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Detalles Bibliográficos
Autores principales: Kalagiri, Rajasree, Stanfield, Robyn L., Meisenhelder, Jill, La Clair, James J., Fuhs, Stephen R., Wilson, Ian A., Hunter, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017925/
https://www.ncbi.nlm.nih.gov/pubmed/33547238
http://dx.doi.org/10.1073/pnas.2010644118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017925/
https://www.ncbi.nlm.nih.gov/pubmed/33547238
http://dx.doi.org/10.1073/pnas.2010644118

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