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Case Report: Ectopic Adrenocortical Carcinoma in the Ovary
Adrenocortical carcinoma (ACC) is a rare malignancy with an incidence of 0.7–2.0 cases/million habitants/year. ACCs are rare and usually endocrinologically functional. We present the case of a 59-year-old woman who experienced abdominal fullness for 6 months and increased abdominal circumference. A...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018272/ https://www.ncbi.nlm.nih.gov/pubmed/33815299 http://dx.doi.org/10.3389/fendo.2021.662377 |
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author | Tsai, Wen-Hsuan Chen, Tze-Chien Dai, Shuen-Han Zeng, Yi-Hong |
author_facet | Tsai, Wen-Hsuan Chen, Tze-Chien Dai, Shuen-Han Zeng, Yi-Hong |
author_sort | Tsai, Wen-Hsuan |
collection | PubMed |
description | Adrenocortical carcinoma (ACC) is a rare malignancy with an incidence of 0.7–2.0 cases/million habitants/year. ACCs are rare and usually endocrinologically functional. We present the case of a 59-year-old woman who experienced abdominal fullness for 6 months and increased abdominal circumference. A large pelvic tumor was observed. She underwent cytoreductive surgery and the pathological test results revealed local tumor necrosis and prominent lympho-vascular invasion. Neuroendocrine carcinoma was the first impression, but positivity for synaptophysin, alpha-inhibin, transcription factor enhancer 3 (TFE-3), calretinin (focal), and CD56 (focal) and high Ki-67-labeling proliferating index (>80%) confirmed the diagnosis of ectopic ACC. Ectopic primary aldosteronism could not be excluded. However, we did not perform saline infusion test or captopril test due to poor performance status. When pathological test reports reveal neuroendocrine features not typically found in the organ being examined, IHC staining should be performed to rule out ectopic ACC. Whether the ectopic ACC is functional or not requires complete survey. |
format | Online Article Text |
id | pubmed-8018272 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80182722021-04-03 Case Report: Ectopic Adrenocortical Carcinoma in the Ovary Tsai, Wen-Hsuan Chen, Tze-Chien Dai, Shuen-Han Zeng, Yi-Hong Front Endocrinol (Lausanne) Endocrinology Adrenocortical carcinoma (ACC) is a rare malignancy with an incidence of 0.7–2.0 cases/million habitants/year. ACCs are rare and usually endocrinologically functional. We present the case of a 59-year-old woman who experienced abdominal fullness for 6 months and increased abdominal circumference. A large pelvic tumor was observed. She underwent cytoreductive surgery and the pathological test results revealed local tumor necrosis and prominent lympho-vascular invasion. Neuroendocrine carcinoma was the first impression, but positivity for synaptophysin, alpha-inhibin, transcription factor enhancer 3 (TFE-3), calretinin (focal), and CD56 (focal) and high Ki-67-labeling proliferating index (>80%) confirmed the diagnosis of ectopic ACC. Ectopic primary aldosteronism could not be excluded. However, we did not perform saline infusion test or captopril test due to poor performance status. When pathological test reports reveal neuroendocrine features not typically found in the organ being examined, IHC staining should be performed to rule out ectopic ACC. Whether the ectopic ACC is functional or not requires complete survey. Frontiers Media S.A. 2021-03-19 /pmc/articles/PMC8018272/ /pubmed/33815299 http://dx.doi.org/10.3389/fendo.2021.662377 Text en Copyright © 2021 Tsai, Chen, Dai and Zeng http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Tsai, Wen-Hsuan Chen, Tze-Chien Dai, Shuen-Han Zeng, Yi-Hong Case Report: Ectopic Adrenocortical Carcinoma in the Ovary |
title | Case Report: Ectopic Adrenocortical Carcinoma in the Ovary |
title_full | Case Report: Ectopic Adrenocortical Carcinoma in the Ovary |
title_fullStr | Case Report: Ectopic Adrenocortical Carcinoma in the Ovary |
title_full_unstemmed | Case Report: Ectopic Adrenocortical Carcinoma in the Ovary |
title_short | Case Report: Ectopic Adrenocortical Carcinoma in the Ovary |
title_sort | case report: ectopic adrenocortical carcinoma in the ovary |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018272/ https://www.ncbi.nlm.nih.gov/pubmed/33815299 http://dx.doi.org/10.3389/fendo.2021.662377 |
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