Control of S phase duration: a replication capacity model with E2F transcription at its heart

DNA replication capacity, the maximal amount of DNA a cell can synthesize at any given time during S phase, is controlled by E2F-dependent transcription. Controlling replication capacity limits the replication rate and provides a robust mechanism to keep replication fork speed within an optimal rang...

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Detalles Bibliográficos
Autores principales: Bertoli, Cosetta, de Bruin, Robertus A.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018357/
https://www.ncbi.nlm.nih.gov/pubmed/33855165
http://dx.doi.org/10.1080/23723556.2020.1839294
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author Bertoli, Cosetta
de Bruin, Robertus A.M.
author_facet Bertoli, Cosetta
de Bruin, Robertus A.M.
author_sort Bertoli, Cosetta
collection PubMed
description DNA replication capacity, the maximal amount of DNA a cell can synthesize at any given time during S phase, is controlled by E2F-dependent transcription. Controlling replication capacity limits the replication rate and provides a robust mechanism to keep replication fork speed within an optimal range whilst ensuring timely completion of genome duplication.
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spelling pubmed-80183572021-04-13 Control of S phase duration: a replication capacity model with E2F transcription at its heart Bertoli, Cosetta de Bruin, Robertus A.M. Mol Cell Oncol Author’s Views DNA replication capacity, the maximal amount of DNA a cell can synthesize at any given time during S phase, is controlled by E2F-dependent transcription. Controlling replication capacity limits the replication rate and provides a robust mechanism to keep replication fork speed within an optimal range whilst ensuring timely completion of genome duplication. Taylor & Francis 2021-03-08 /pmc/articles/PMC8018357/ /pubmed/33855165 http://dx.doi.org/10.1080/23723556.2020.1839294 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Bertoli, Cosetta
de Bruin, Robertus A.M.
Control of S phase duration: a replication capacity model with E2F transcription at its heart
title Control of S phase duration: a replication capacity model with E2F transcription at its heart
title_full Control of S phase duration: a replication capacity model with E2F transcription at its heart
title_fullStr Control of S phase duration: a replication capacity model with E2F transcription at its heart
title_full_unstemmed Control of S phase duration: a replication capacity model with E2F transcription at its heart
title_short Control of S phase duration: a replication capacity model with E2F transcription at its heart
title_sort control of s phase duration: a replication capacity model with e2f transcription at its heart
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018357/
https://www.ncbi.nlm.nih.gov/pubmed/33855165
http://dx.doi.org/10.1080/23723556.2020.1839294
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