Targeting gliomas with STAT3-silencing nanoparticles

Glioblastoma is an aggressive brain tumor with poor prognosis. The brain is protected by the blood–brain barrier, which precludes transport of chemotherapeutics. We developed nanoparticles that achieve delivery of small-interfering RNA against Stat3 after systemic administration. Nanoparticles combi...

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Detalles Bibliográficos
Autores principales: Kadiyala, Padma, Gregory, Jason V., Lowenstein, Pedro R., Lahann, Joerg, Castro, Maria G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018361/
https://www.ncbi.nlm.nih.gov/pubmed/33855166
http://dx.doi.org/10.1080/23723556.2020.1870647
Descripción
Sumario:Glioblastoma is an aggressive brain tumor with poor prognosis. The brain is protected by the blood–brain barrier, which precludes transport of chemotherapeutics. We developed nanoparticles that achieve delivery of small-interfering RNA against Stat3 after systemic administration. Nanoparticles combined with radiation inhibited tumor progression and elicited anti-glioblastoma immunity in mice.

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