Targeting gliomas with STAT3-silencing nanoparticles

Glioblastoma is an aggressive brain tumor with poor prognosis. The brain is protected by the blood–brain barrier, which precludes transport of chemotherapeutics. We developed nanoparticles that achieve delivery of small-interfering RNA against Stat3 after systemic administration. Nanoparticles combi...

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Detalles Bibliográficos
Autores principales: Kadiyala, Padma, Gregory, Jason V., Lowenstein, Pedro R., Lahann, Joerg, Castro, Maria G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018361/
https://www.ncbi.nlm.nih.gov/pubmed/33855166
http://dx.doi.org/10.1080/23723556.2020.1870647
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author Kadiyala, Padma
Gregory, Jason V.
Lowenstein, Pedro R.
Lahann, Joerg
Castro, Maria G.
author_facet Kadiyala, Padma
Gregory, Jason V.
Lowenstein, Pedro R.
Lahann, Joerg
Castro, Maria G.
author_sort Kadiyala, Padma
collection PubMed
description Glioblastoma is an aggressive brain tumor with poor prognosis. The brain is protected by the blood–brain barrier, which precludes transport of chemotherapeutics. We developed nanoparticles that achieve delivery of small-interfering RNA against Stat3 after systemic administration. Nanoparticles combined with radiation inhibited tumor progression and elicited anti-glioblastoma immunity in mice.
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spelling pubmed-80183612021-04-13 Targeting gliomas with STAT3-silencing nanoparticles Kadiyala, Padma Gregory, Jason V. Lowenstein, Pedro R. Lahann, Joerg Castro, Maria G. Mol Cell Oncol Commentary Glioblastoma is an aggressive brain tumor with poor prognosis. The brain is protected by the blood–brain barrier, which precludes transport of chemotherapeutics. We developed nanoparticles that achieve delivery of small-interfering RNA against Stat3 after systemic administration. Nanoparticles combined with radiation inhibited tumor progression and elicited anti-glioblastoma immunity in mice. Taylor & Francis 2021-01-31 /pmc/articles/PMC8018361/ /pubmed/33855166 http://dx.doi.org/10.1080/23723556.2020.1870647 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Commentary
Kadiyala, Padma
Gregory, Jason V.
Lowenstein, Pedro R.
Lahann, Joerg
Castro, Maria G.
Targeting gliomas with STAT3-silencing nanoparticles
title Targeting gliomas with STAT3-silencing nanoparticles
title_full Targeting gliomas with STAT3-silencing nanoparticles
title_fullStr Targeting gliomas with STAT3-silencing nanoparticles
title_full_unstemmed Targeting gliomas with STAT3-silencing nanoparticles
title_short Targeting gliomas with STAT3-silencing nanoparticles
title_sort targeting gliomas with stat3-silencing nanoparticles
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018361/
https://www.ncbi.nlm.nih.gov/pubmed/33855166
http://dx.doi.org/10.1080/23723556.2020.1870647
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