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Prevalence, species distribution, and risk factors of fungal colonization and infection in patients at a burn intensive care unit in Vietnam

BACKGROUND AND PURPOSE : Burn patients are at a higher risk of infections caused by different organisms. This study aimed to address the prevalence, causative species, and factors related to fungal colonization or infection in patients with acute severe injuries admitted to the intensive care unit (...

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Autores principales: Van Bang, Be Nguyen, Thanh Xuan, Nguyen, Xuan Quang, Dinh, Ba Loi, Cao, Thai Ngoc Minh, Nguyen, Nhu Lam, Nguyen, Ngoc Anh, Do, Thi Thu Hien, Truong, Xuan Su, Hoang, Tran-Anh, Le
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Society of Medical Mycology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018815/
https://www.ncbi.nlm.nih.gov/pubmed/33834142
http://dx.doi.org/10.18502/cmm.6.3.4664
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author Van Bang, Be Nguyen
Thanh Xuan, Nguyen
Xuan Quang, Dinh
Ba Loi, Cao
Thai Ngoc Minh, Nguyen
Nhu Lam, Nguyen
Ngoc Anh, Do
Thi Thu Hien, Truong
Xuan Su, Hoang
Tran-Anh, Le
author_facet Van Bang, Be Nguyen
Thanh Xuan, Nguyen
Xuan Quang, Dinh
Ba Loi, Cao
Thai Ngoc Minh, Nguyen
Nhu Lam, Nguyen
Ngoc Anh, Do
Thi Thu Hien, Truong
Xuan Su, Hoang
Tran-Anh, Le
author_sort Van Bang, Be Nguyen
collection PubMed
description BACKGROUND AND PURPOSE : Burn patients are at a higher risk of infections caused by different organisms. This study aimed to address the prevalence, causative species, and factors related to fungal colonization or infection in patients with acute severe injuries admitted to the intensive care unit (ICU) of a burn hospital in northern Vietnam. MATERIALS AND METHODS: This prospective study was conducted on 400 patients in a burn ICU between 2017 and 2019. Clinical samples were weekly collected and screened for fungi, and relevant clinical information was obtained from medical records. RESULTS: According to the results, 90% of the patients were colonized with fungi. Out of this group, 12.75% of the cases had invasive fungal infection (IFI). Eleven yeasts and six mold species were isolated from the patients, with the most common species being Candida tropicalis (45.56%) and C. albicans (41.94%). Among the eleven species causing fungal wound infection (FWI), the most common agents were Candida (66.7% of FWI patients) and Aspergillus (38.5%) species. Three Candida species isolated from blood were C. tropicalis (66.7%), C. albicans (20.0%), and C. parapsilosis (14.3%). No factors were found to expose the patients to a higher risk of fungal colonization. However, hyperglycemia, prolonged ICU stay, and heavy Candida species colonization were found to be independently predictive of IFI. CONCLUSION: Burn patients are at the risk of fungal infection with Candida species (especially C. tropicalis) and Aspergillus as the most frequently responsible agents. Continuous surveillance of fungi and appropriate management of pathophysiological consequences are essential to prevent fungal infection in burn patients.
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spelling pubmed-80188152021-04-07 Prevalence, species distribution, and risk factors of fungal colonization and infection in patients at a burn intensive care unit in Vietnam Van Bang, Be Nguyen Thanh Xuan, Nguyen Xuan Quang, Dinh Ba Loi, Cao Thai Ngoc Minh, Nguyen Nhu Lam, Nguyen Ngoc Anh, Do Thi Thu Hien, Truong Xuan Su, Hoang Tran-Anh, Le Curr Med Mycol Original Article BACKGROUND AND PURPOSE : Burn patients are at a higher risk of infections caused by different organisms. This study aimed to address the prevalence, causative species, and factors related to fungal colonization or infection in patients with acute severe injuries admitted to the intensive care unit (ICU) of a burn hospital in northern Vietnam. MATERIALS AND METHODS: This prospective study was conducted on 400 patients in a burn ICU between 2017 and 2019. Clinical samples were weekly collected and screened for fungi, and relevant clinical information was obtained from medical records. RESULTS: According to the results, 90% of the patients were colonized with fungi. Out of this group, 12.75% of the cases had invasive fungal infection (IFI). Eleven yeasts and six mold species were isolated from the patients, with the most common species being Candida tropicalis (45.56%) and C. albicans (41.94%). Among the eleven species causing fungal wound infection (FWI), the most common agents were Candida (66.7% of FWI patients) and Aspergillus (38.5%) species. Three Candida species isolated from blood were C. tropicalis (66.7%), C. albicans (20.0%), and C. parapsilosis (14.3%). No factors were found to expose the patients to a higher risk of fungal colonization. However, hyperglycemia, prolonged ICU stay, and heavy Candida species colonization were found to be independently predictive of IFI. CONCLUSION: Burn patients are at the risk of fungal infection with Candida species (especially C. tropicalis) and Aspergillus as the most frequently responsible agents. Continuous surveillance of fungi and appropriate management of pathophysiological consequences are essential to prevent fungal infection in burn patients. Iranian Society of Medical Mycology 2020-09 /pmc/articles/PMC8018815/ /pubmed/33834142 http://dx.doi.org/10.18502/cmm.6.3.4664 Text en Copyright: © 2020, Published by Mazandaran University of Medical Sciences on behalf of Iranian Society of Medical Mycology and Invasive Fungi Research Center. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 Unported License, ( http://creativecommons.org/licenses/by/4.0/ ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Van Bang, Be Nguyen
Thanh Xuan, Nguyen
Xuan Quang, Dinh
Ba Loi, Cao
Thai Ngoc Minh, Nguyen
Nhu Lam, Nguyen
Ngoc Anh, Do
Thi Thu Hien, Truong
Xuan Su, Hoang
Tran-Anh, Le
Prevalence, species distribution, and risk factors of fungal colonization and infection in patients at a burn intensive care unit in Vietnam
title Prevalence, species distribution, and risk factors of fungal colonization and infection in patients at a burn intensive care unit in Vietnam
title_full Prevalence, species distribution, and risk factors of fungal colonization and infection in patients at a burn intensive care unit in Vietnam
title_fullStr Prevalence, species distribution, and risk factors of fungal colonization and infection in patients at a burn intensive care unit in Vietnam
title_full_unstemmed Prevalence, species distribution, and risk factors of fungal colonization and infection in patients at a burn intensive care unit in Vietnam
title_short Prevalence, species distribution, and risk factors of fungal colonization and infection in patients at a burn intensive care unit in Vietnam
title_sort prevalence, species distribution, and risk factors of fungal colonization and infection in patients at a burn intensive care unit in vietnam
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018815/
https://www.ncbi.nlm.nih.gov/pubmed/33834142
http://dx.doi.org/10.18502/cmm.6.3.4664
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