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A novel anti-human IL-1R7 antibody reduces IL-18-mediated inflammatory signaling

Unchecked inflammation can result in severe diseases with high mortality, such as macrophage activation syndrome (MAS). MAS and associated cytokine storms have been observed in COVID-19 patients exhibiting systemic hyperinflammation. Interleukin-18 (IL-18), a proinflammatory cytokine belonging to th...

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Detalles Bibliográficos
Autores principales:	Li, Suzhao, Jiang, Liqiong, Beckmann, Karsten, Højen, Jesper Falkesgaard, Pessara, Ulrich, Powers, Nicholas E., de Graaf, Dennis M., Azam, Tania, Lindenberger, Jared, Eisenmesser, Elan Z., Fischer, Stephan, Dinarello, Charles A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018910/ https://www.ncbi.nlm.nih.gov/pubmed/33823154 http://dx.doi.org/10.1016/j.jbc.2021.100630

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