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Interactive tool to create adjustable anatomical atlases for mouse brain imaging

OBJECTIVE: Brain atlases are important research tools enabling researchers to focus their investigations on specific anatomically defined brain regions and are used in many MRI applications, e.g. in fMRI, morphometry, whole brain spectroscopy, et cetera. Despite their extensive use and numerous vers...

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Detalles Bibliográficos
Autores principales: Sack, Markus, Zheng, Lei, Gass, Natalia, Ende, Gabriele, Sartorius, Alexander, Weber-Fahr, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018930/
https://www.ncbi.nlm.nih.gov/pubmed/32696290
http://dx.doi.org/10.1007/s10334-020-00866-0
Descripción
Sumario:OBJECTIVE: Brain atlases are important research tools enabling researchers to focus their investigations on specific anatomically defined brain regions and are used in many MRI applications, e.g. in fMRI, morphometry, whole brain spectroscopy, et cetera. Despite their extensive use and numerous versions they usually consist of predefined rigid brain regions with a given level of detail often degrading them to a non-ideal tool in special research topics. RESULT: To overcome this intrinsic weakness we present a graphical user interface application which allows researchers to easily create mouse brain atlases with an adjustable user-defined level of detail and coverage to match specific research questions.