Modified Snake α-Neurotoxin Averts β-Amyloid Binding to α7 Nicotinic Acetylcholine Receptor and Reverses Cognitive Deficits in Alzheimer’s Disease Mice

Alzheimer’s disease (AD) is the most common cause of senile dementia and one of the greatest medical, social, and economic challenges. According to a dominant theory, amyloid-β (Aβ) peptide is a key AD pathogenic factor. Aβ-soluble species interfere with synaptic functions, aggregate gradually, form...

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Detalles Bibliográficos
Autores principales: Fonar, Gennadiy, Polis, Baruh, Sams, Dev Sharan, Levi, Almog, Malka, Assaf, Bal, Natalia, Maltsev, Alexander, Elliott, Evan, Samson, Abraham O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018932/
https://www.ncbi.nlm.nih.gov/pubmed/33417228
http://dx.doi.org/10.1007/s12035-020-02270-0

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