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Detection of loci exhibiting pleiotropic effects on body weight and egg number in female broilers

The objective of the present study was to discover the genetic variants, functional candidate genes, biological processes and molecular functions underlying the negative genetic correlation observed between body weight (BW) and egg number (EN) traits in female broilers. To this end, first a bivariat...

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Autores principales: Tarsani, Eirini, Kranis, Andreas, Maniatis, Gerasimos, Hager-Theodorides, Ariadne L., Kominakis, Antonios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018976/
https://www.ncbi.nlm.nih.gov/pubmed/33811218
http://dx.doi.org/10.1038/s41598-021-86817-8
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author Tarsani, Eirini
Kranis, Andreas
Maniatis, Gerasimos
Hager-Theodorides, Ariadne L.
Kominakis, Antonios
author_facet Tarsani, Eirini
Kranis, Andreas
Maniatis, Gerasimos
Hager-Theodorides, Ariadne L.
Kominakis, Antonios
author_sort Tarsani, Eirini
collection PubMed
description The objective of the present study was to discover the genetic variants, functional candidate genes, biological processes and molecular functions underlying the negative genetic correlation observed between body weight (BW) and egg number (EN) traits in female broilers. To this end, first a bivariate genome-wide association and second stepwise conditional-joint analyses were performed using 2586 female broilers and 240 k autosomal SNPs. The aforementioned analyses resulted in a total number of 49 independent cross-phenotype (CP) significant SNPs with 35 independent markers showing antagonistic action i.e., positive effects on one trait and negative effects on the other trait. A number of 33 independent CP SNPs were located within 26 and 14 protein coding and long non-coding RNA genes, respectively. Furthermore, 26 independent markers were situated within 44 reported QTLs, most of them related to growth traits. Investigation of the functional role of protein coding genes via pathway and gene ontology analyses highlighted four candidates (CPEB3, ACVR1, MAST2 and CACNA1H) as most plausible pleiotropic genes for the traits under study. Three candidates (CPEB3, MAST2 and CACNA1H) were associated with antagonistic pleiotropy, while ACVR1 with synergistic pleiotropic action. Current results provide a novel insight into the biological mechanism of the genetic trade-off between growth and reproduction, in broilers.
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spelling pubmed-80189762021-04-07 Detection of loci exhibiting pleiotropic effects on body weight and egg number in female broilers Tarsani, Eirini Kranis, Andreas Maniatis, Gerasimos Hager-Theodorides, Ariadne L. Kominakis, Antonios Sci Rep Article The objective of the present study was to discover the genetic variants, functional candidate genes, biological processes and molecular functions underlying the negative genetic correlation observed between body weight (BW) and egg number (EN) traits in female broilers. To this end, first a bivariate genome-wide association and second stepwise conditional-joint analyses were performed using 2586 female broilers and 240 k autosomal SNPs. The aforementioned analyses resulted in a total number of 49 independent cross-phenotype (CP) significant SNPs with 35 independent markers showing antagonistic action i.e., positive effects on one trait and negative effects on the other trait. A number of 33 independent CP SNPs were located within 26 and 14 protein coding and long non-coding RNA genes, respectively. Furthermore, 26 independent markers were situated within 44 reported QTLs, most of them related to growth traits. Investigation of the functional role of protein coding genes via pathway and gene ontology analyses highlighted four candidates (CPEB3, ACVR1, MAST2 and CACNA1H) as most plausible pleiotropic genes for the traits under study. Three candidates (CPEB3, MAST2 and CACNA1H) were associated with antagonistic pleiotropy, while ACVR1 with synergistic pleiotropic action. Current results provide a novel insight into the biological mechanism of the genetic trade-off between growth and reproduction, in broilers. Nature Publishing Group UK 2021-04-02 /pmc/articles/PMC8018976/ /pubmed/33811218 http://dx.doi.org/10.1038/s41598-021-86817-8 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Tarsani, Eirini
Kranis, Andreas
Maniatis, Gerasimos
Hager-Theodorides, Ariadne L.
Kominakis, Antonios
Detection of loci exhibiting pleiotropic effects on body weight and egg number in female broilers
title Detection of loci exhibiting pleiotropic effects on body weight and egg number in female broilers
title_full Detection of loci exhibiting pleiotropic effects on body weight and egg number in female broilers
title_fullStr Detection of loci exhibiting pleiotropic effects on body weight and egg number in female broilers
title_full_unstemmed Detection of loci exhibiting pleiotropic effects on body weight and egg number in female broilers
title_short Detection of loci exhibiting pleiotropic effects on body weight and egg number in female broilers
title_sort detection of loci exhibiting pleiotropic effects on body weight and egg number in female broilers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018976/
https://www.ncbi.nlm.nih.gov/pubmed/33811218
http://dx.doi.org/10.1038/s41598-021-86817-8
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