Potentiating CD8(+) T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling

Metabolic regulation has been proven to play a critical role in T cell antitumor immunity. However, cholesterol metabolism as a key component of this regulation remains largely unexplored. Herein, we found that the low-density lipoprotein receptor (LDLR), which has been previously identified as a tr...

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Detalles Bibliográficos
Autores principales: Yuan, Juanjuan, Cai, Ting, Zheng, Xiaojun, Ren, Yangzi, Qi, Jingwen, Lu, Xiaofei, Chen, Huihui, Lin, Huizhen, Chen, Zijie, Liu, Mengnan, He, Shangwen, Chen, Qijun, Feng, Siyang, Wu, Yingjun, Zhang, Zhenhai, Ding, Yanqing, Yang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018994/
https://www.ncbi.nlm.nih.gov/pubmed/33606190
http://dx.doi.org/10.1007/s13238-021-00821-2

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