Interleukin-17 and Interleukin-23: A Narrative Review of Mechanisms of Action in Psoriasis and Associated Comorbidities

Psoriasis is an immune-mediated inflammatory skin disease associated with numerous inflammatory comorbidities, including increased cardiovascular risk. The interleukin (IL)-23/IL-17 axis plays a central role in the immunopathogenesis of psoriasis and related comorbidities by acting to stimulate kera...

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Autores principales: Menter, Alan, Krueger, Gerald G., Paek, So Yeon, Kivelevitch, Dario, Adamopoulos, Iannis E., Langley, Richard G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019008/
https://www.ncbi.nlm.nih.gov/pubmed/33512665
http://dx.doi.org/10.1007/s13555-021-00483-2
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author Menter, Alan
Krueger, Gerald G.
Paek, So Yeon
Kivelevitch, Dario
Adamopoulos, Iannis E.
Langley, Richard G.
author_facet Menter, Alan
Krueger, Gerald G.
Paek, So Yeon
Kivelevitch, Dario
Adamopoulos, Iannis E.
Langley, Richard G.
author_sort Menter, Alan
collection PubMed
description Psoriasis is an immune-mediated inflammatory skin disease associated with numerous inflammatory comorbidities, including increased cardiovascular risk. The interleukin (IL)-23/IL-17 axis plays a central role in the immunopathogenesis of psoriasis and related comorbidities by acting to stimulate keratinocyte hyperproliferation and feed-forwarding circuits of perpetual T cell-mediated inflammation. IL-17 plays an important role in the downstream portion of the psoriatic inflammatory cascade. This review discusses the distinct mechanisms of action of IL-17 and IL-23 in the immunopathogenesis of psoriasis and related comorbidities plus the significant therapeutic benefits of selectively inhibiting these cytokines in patients with moderate to severe plaque psoriasis.
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spelling pubmed-80190082021-04-16 Interleukin-17 and Interleukin-23: A Narrative Review of Mechanisms of Action in Psoriasis and Associated Comorbidities Menter, Alan Krueger, Gerald G. Paek, So Yeon Kivelevitch, Dario Adamopoulos, Iannis E. Langley, Richard G. Dermatol Ther (Heidelb) Review Psoriasis is an immune-mediated inflammatory skin disease associated with numerous inflammatory comorbidities, including increased cardiovascular risk. The interleukin (IL)-23/IL-17 axis plays a central role in the immunopathogenesis of psoriasis and related comorbidities by acting to stimulate keratinocyte hyperproliferation and feed-forwarding circuits of perpetual T cell-mediated inflammation. IL-17 plays an important role in the downstream portion of the psoriatic inflammatory cascade. This review discusses the distinct mechanisms of action of IL-17 and IL-23 in the immunopathogenesis of psoriasis and related comorbidities plus the significant therapeutic benefits of selectively inhibiting these cytokines in patients with moderate to severe plaque psoriasis. Springer Healthcare 2021-01-29 /pmc/articles/PMC8019008/ /pubmed/33512665 http://dx.doi.org/10.1007/s13555-021-00483-2 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Review
Menter, Alan
Krueger, Gerald G.
Paek, So Yeon
Kivelevitch, Dario
Adamopoulos, Iannis E.
Langley, Richard G.
Interleukin-17 and Interleukin-23: A Narrative Review of Mechanisms of Action in Psoriasis and Associated Comorbidities
title Interleukin-17 and Interleukin-23: A Narrative Review of Mechanisms of Action in Psoriasis and Associated Comorbidities
title_full Interleukin-17 and Interleukin-23: A Narrative Review of Mechanisms of Action in Psoriasis and Associated Comorbidities
title_fullStr Interleukin-17 and Interleukin-23: A Narrative Review of Mechanisms of Action in Psoriasis and Associated Comorbidities
title_full_unstemmed Interleukin-17 and Interleukin-23: A Narrative Review of Mechanisms of Action in Psoriasis and Associated Comorbidities
title_short Interleukin-17 and Interleukin-23: A Narrative Review of Mechanisms of Action in Psoriasis and Associated Comorbidities
title_sort interleukin-17 and interleukin-23: a narrative review of mechanisms of action in psoriasis and associated comorbidities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019008/
https://www.ncbi.nlm.nih.gov/pubmed/33512665
http://dx.doi.org/10.1007/s13555-021-00483-2
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